{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:27:51Z","timestamp":1784129271258,"version":"3.55.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1-2","funder":[{"name":"None"},{"name":"None"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Low back pain (LBP) is highly prevalent after lower limb amputation (LLA) and contributes to substantial reductions in quality of life and function. Towards understanding pathophysiological mechanisms underlying LBP after LLA, this article compares lumbar spine pathologies and muscle morphologies between individuals with LBP, with and without LLA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>We queried electronic medical records of Service members with and without LLA who sought care for LBP at military treatment facilities between January 2002 and May 2020. Two groups with cLBP, one with (n\u2009=\u200915) and one without unilateral transtibial LLA (n\u2009=\u200915), were identified and randomly chosen from a larger sample. Groups were matched by age, mass, and sex. Lumbar muscle morphology, Pfirrmann grades, Modic changes, facet arthrosis, Meyerding grades, and lordosis angle were determined from radiographs and magnetic resonance images available in the medical record. Independent t-tests compared variables between cohorts while multiple regression models determined if intramuscular fat influenced Pfirrmann grades. Chi-square determined differences in presence of spondylolysis and facet arthrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lordosis angle was larger with LLA (P\u2009=\u20090.01). Spondylolysis was more prevalent with LLA (P\u2009=\u20090.008; 40%) whereas facet arthrosis was similar between cohorts (P\u2009=\u20090.3). Muscle area was not different between cohorts, yet intramuscular fat was greater with LLA (P\u2009\u2264\u20090.05). Intramuscular fat did not influence Pfirrmann grades (P\u2009&amp;gt;\u20090.15).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite similar lumbar muscle size, those with unilateral LLA may be predisposed to progress to symptomatic spondylolisthesis and intramuscular fat. Surgical and\/or rehabilitation interventions may mitigate long-term effects of diminished spinal health, decrease LBP-related disability, and improve function for individuals with LLA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usae306","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T18:13:57Z","timestamp":1719512037000},"page":"e54-e58","source":"Crossref","is-referenced-by-count":1,"title":["Spinal Pathology and Muscle Morphologies with Chronic Low Back Pain and Lower Limb Amputation"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-5388","authenticated-orcid":false,"given":"Courtney M","family":"Butowicz","sequence":"first","affiliation":[{"name":"Research & Surveillance Section, Extremity Trauma and Amputation Center of Excellence, Defense Health Agency , Falls Church, VA 22042,","place":["USA"]},{"name":"Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Physical Medicine & Rehabilitation, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin D","family":"Helgeson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Orthopaedics, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred J","family":"Pisano","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Orthopaedics, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Orthopaedics, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Cherry","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Orthopaedics, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L","family":"Dearth","sequence":"additional","affiliation":[{"name":"Research & Surveillance Section, Extremity Trauma and Amputation Center of Excellence, Defense Health Agency , Falls Church, VA 22042,","place":["USA"]},{"name":"Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Surgery, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad D","family":"Hendershot","sequence":"additional","affiliation":[{"name":"Research & Surveillance Section, Extremity Trauma and Amputation Center of Excellence, Defense Health Agency , Falls Church, VA 22042,","place":["USA"]},{"name":"Department of Rehabilitation, Walter Reed National Military Medical Center , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Physical Medicine & Rehabilitation, Uniformed Services University of the Health Sciences , Bethesda, MD 20814,","place":["USA"]},{"name":"Department of Surgery, Uniformed Services University 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