{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:23:33Z","timestamp":1788049413552,"version":"build-2784847793"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1-2","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"State Space Labs"},{"name":"State Space Labs"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,16]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Hypoxia presents a physiological challenge to the Warfighters during military aviation and subterranean warfare operations by decreasing the supply of oxygen to the brain, which results in a reduced cognitive function depending on the magnitude and duration of hypoxic exposure. Moderate hypoxic exposures, fractions of inspired oxygen (FiO2) of 0.11 to 0.14, show no effects on simple tasks, but complex tasks like working memory may be hindered. Unfortunately, people often cannot recognize their own symptoms of hypoxemia, which are individualistic at moderate hypoxic exposure. Thus, screening tools, like gamified cognitive assessments, during moderate hypoxia may provide personnel objective feedback to initiate safety protocols before a possible accident. However, whether gamified assessments of working memory are sensitive to moderate hypoxia is unknown. Therefore, we tested the hypothesis which moderate normobaric hypoxia decreases gamified working memory performance when accounting for the individualistic responses of arterial blood oxygen saturations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>Following 3 consecutive days of 2 practice sessions per day, 30 healthy adults (25\u2009\u00b1\u20095 years, 10 women) completed three 1-min rounds of the tablet-based working memory game (Backtracker, Statespace Labs, Inc.) at baseline and 60 and 90\u2009min after exposure to FiO2\u2009(=\u20090.138\u2009\u00b1\u20090.002 [hypoxia] and 0.201\u00b1 0.004 [normoxia] oxygen). Both conditions were completed on the same day and administered in a single-blind, block randomized manner. Arterial oxyhemoglobin saturation was estimated via forehead pulse oximetry (SpO2). Data were analyzed using linear mixed effects modeling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared to normoxia (99\u2009\u00b1\u20091%), SpO2 was lower (P\u2009&amp;lt;\u2009.001) at 60 (90\u2009\u00b1\u20092%) and 90 (90\u2009\u00b1\u20092%) min of hypoxia. A decrease in SpO2 was associated with a statistically significant decrease in the proportion of both tiles with the correct location (P\u2009&amp;lt;\u2009.02; \u22120.016) and correct order of appearance recalled (P\u2009&amp;lt;\u2009.01; \u22120.016). A decrease in SpO2 was associated with a statistically significant decrease in median time to first tap (P\u2009&amp;lt;\u2009.01; \u22120.041\u00a0s) and median time between taps (P\u00a0&amp;lt;\u00a0.01; \u22120.030\u00a0s). A significant interaction effect between the SpO2 decrease and baseline performance was found for proportion of tiles with the correct location recalled (P\u2009&amp;lt;\u2009.05; \u22120.014), median time to first tap (P &amp;lt;\u00a0.01; \u22120.070\u00a0s), and median time between taps (P\u2009&amp;lt;\u2009.01; \u22120.037\u00a0s). A significant interaction effect between the SpO2 decrease and the path length was found for the proportion of tiles with the correct location recalled (P\u2009&amp;lt;\u2009.01; +0.021), median time to first tap (P\u2009&amp;lt;\u2009.01; \u22120.036\u00a0s), and median time between taps (P\u2009&amp;lt;\u2009.01; \u22120.043\u00a0s).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings indicate that greater decreases in SpO2 during moderate hypoxic exposure hinder performance on a gamified assessment of working memory as measured by the proportion of correctly identified order and location of tiles. Considering the statistically significant decrease in both median time to first tap and median time between taps associated with the decrease in SpO2, participants are taking less time to plan or execute movements, which may compound or independently contribute to spatial and temporal memory mistakes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usae376","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T11:41:54Z","timestamp":1722858114000},"page":"e171-e179","source":"Crossref","is-referenced-by-count":1,"title":["Arterial Oxygen Desaturation Hinders Gamified Working Memory Performance"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-2306","authenticated-orcid":false,"given":"Jason M","family":"Keeler","sequence":"first","affiliation":[{"name":"H.H. Morris Human Performance Laboratories, Department of Kinesiology, Indiana University School of Public Health , Bloomington, IN 47405,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4339-5212","authenticated-orcid":false,"given":"Jennifer B","family":"Listman","sequence":"additional","affiliation":[{"name":"Statespace Labs, Inc. , New York, NY 10012,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Jo","family":"Hite","sequence":"additional","affiliation":[{"name":"H.H. Morris Human Performance Laboratories, Department of Kinesiology, Indiana University School of Public Health , Bloomington, IN 47405,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3282-9898","authenticated-orcid":false,"given":"David J","family":"Heeger","sequence":"additional","affiliation":[{"name":"Statespace Labs, Inc. , New York, NY 10012,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Tourula","sequence":"additional","affiliation":[{"name":"H.H. 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