{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:27:33Z","timestamp":1786120053250,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","funder":[{"name":"Opportunity Funds Management Core of the Centers for Medical Countermeasures"},{"name":"Radiation, National Institute of Allergy and Infectious Diseases","award":["U19AI067773"],"award-info":[{"award-number":["U19AI067773"]}]},{"DOI":"10.13039\/100012414","name":"AFRRI","doi-asserted-by":"publisher","award":["AFR-B2-12985"],"award-info":[{"award-number":["AFR-B2-12985"]}],"id":[{"id":"10.13039\/100012414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AAI26003-001-00000"],"award-info":[{"award-number":["AAI26003-001-00000"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ionizing radiation exposure can cause acute radiation syndrome (ARS) with life-threatening multi-organ damage. Although several hematopoietic growth factors are FDA-approved as radiation countermeasures, alternative strategies that target inflammatory mechanisms remain urgently needed. TO-207, formerly known as JTE-607, is a selective multi-cytokine inhibitor that suppresses pro-inflammatory cytokine secretion in human monocytes and macrophages. TO-207 represents a mechanistically distinct radiation mitigator; however, whether it suppresses the acute post-irradiation cytokine surge in vivo has not yet been directly demonstrated and remains to be confirmed in future studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Male CD2F1 mice were exposed to lethal total-body irradiation (TBI, 9.0 Gy, LD70\/30). Mice received TO-207 (100 mg\/kg, s.c.) or vehicle once daily for 3 consecutive days, starting at 24 hours after irradiation. Outcomes included 30-day survival, peripheral blood recovery, bone marrow clonogenic capacity, and serum cytokine profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TO-207 treatment improved survival to 65% compared to 45% in vehicle controls. Hematopoietic recovery was enhanced, with significant increases in colony-forming unit\u2013granulocyte\/macrophage (CFU-GM) and higher circulating monocyte counts on day 30. Serum cytokine profiling on day 30 revealed that 3 of 44 cytokines (G-CSF, KC, TNF-\u03b1) showed nominally significant differences between groups; however, none remained significant after Benjamini\u2013Hochberg correction for multiple comparisons. These day-30 cytokine observations are exploratory and reflect patterns of altered immune reconstitution rather than direct evidence of acute cytokine suppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TO-207 significantly mitigated hematopoietic injury and improved survival when administered 24 hours after lethal irradiation. These findings highlight TO-207 as a promising candidate for development as a medical countermeasure for ARS. Future studies incorporating early cytokine time points, dose optimization, and both sexes are needed to substantiate the mechanistic hypothesis and maximize translational impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/milmed\/usag230","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:37:23Z","timestamp":1778153843000},"page":"683-689","source":"Crossref","is-referenced-by-count":0,"title":["TO-207 Mitigates Radiation-Induced Hematopoietic Injury in a Murine Model of Lethal Total-Body Irradiation"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-8601","authenticated-orcid":false,"given":"Wanchang","family":"Cui","sequence":"first","affiliation":[{"name":"Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences , Bethesda, MD 20889,","place":["United 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