{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:17:56Z","timestamp":1781014676658,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herpes zoster (HZ, shingles) affects individuals (60+ years) by reactivation of varicella virus from primary infection. Approximately one-third of the general population will develop HZ and are at increased risk of stroke. Our objective was describing possible associations between self-reported HZ vaccination and stroke with the Centers for Disease Control and Prevention\u2019s Behavioral Risk Factors Surveillance System, a cross-sectional nationwide telephone survey. Non-institutionalized U.S. adults answered items concerning health risk behaviors. 2014 survey data were from 265,568 adults 50\u201379 years old. Multivariable Cox regressions adjusted for standard demographics, body mass index, and coronary heart disease showed that HZ-vaccinated individuals had lower risk of reporting stroke those not vaccinated (hazard ratio [HR] = 1.73). After stratification of participants into six 5-year age groups, adjusted weighted binary logistic regressions were conducted for each age group with stroke as outcome. The HZ-vaccinated group aged 65\u201369 years reported stroke approximately 50% less than those unvaccinated (adjusted Odds Ratio [aOR] = 1.51; 99% confidence interval [CI]:1.21,1.88). Secondary analyses indicated that this benefit was among HZ-vaccinated whites (aOR = 1.6, 95%CI:1.4,2.0), but not African Americans or Hispanics. These possible protective effects are not detected 10 years after recommended vaccine uptake. Limitations include not following participants longitudinally and that time between stroke and vaccination could not be determined.<\/jats:p>","DOI":"10.1093\/milmed\/usy343","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T16:04:52Z","timestamp":1553270692000},"page":"126-132","source":"Crossref","is-referenced-by-count":27,"title":["An Association Between Herpes Zoster Vaccination and Stroke Reduction Among Elderly Individuals"],"prefix":"10.1093","volume":"184","author":[{"given":"John S","family":"Klaric","sequence":"first","affiliation":[{"name":"Department of Clinical Investigation, Womack Army Medical Center, 2817 Reilly Road, Fort Bragg, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Clinical Investigation, Womack Army Medical Center, 2817 Reilly Road, Fort Bragg, 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