{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:00:18Z","timestamp":1769151618284,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Y1-AI-5072"],"award-info":[{"award-number":["Y1-AI-5072"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Infectious Disease Clinical Research Program","award":["IDCRP-024"],"award-info":[{"award-number":["IDCRP-024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We examined antibiotic management of combat-related extremity wound infections (CEWI) among wounded U.S. military personnel (2009\u20132012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were included if they sustained blast injuries, resulting in \u22651 open extremity wound, were admitted to participating U.S. hospitals, developed a CEWI (osteomyelitis or deep soft-tissue infections) within 30\u00a0days post-injury, and received \u22653\u00a0days of relevant antibiotic (s) for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 267 patients, 133 (50%) had only a CEWI, while 134 (50%) had a CEWI plus concomitant non-extremity infection. In the pre-diagnosis period (4\u201310\u00a0days prior to CEWI diagnosis), 95 (36%) patients started a new antibiotic with 28% of patients receiving \u22652 antibiotics. During CEWI diagnosis week (\u00b13\u00a0days of diagnosis), 209 (78%) patients started a new antibiotic (71% with \u22652 antibiotics). In the week following diagnosis (4\u201310\u00a0days after CEWI diagnosis), 121 (45%) patients started a new antibiotic with 39% receiving \u22652 antibiotics. Restricting to \u00b17\u00a0days of CEWI diagnosis, patients commonly received two (35%) or three (27%) antibiotics with frequent combinations involving carbapenem, vancomycin, and fluoroquinolones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Substantial variation in antibiotic prescribing patterns related to CEWIs warrants development of combat-related clinical practice guidelines beyond infection prevention, to include strategies to reduce the use of unnecessary antibiotics and improve stewardship.<\/jats:p><\/jats:sec>","DOI":"10.1093\/milmed\/usz211","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T20:00:43Z","timestamp":1582142443000},"page":"628-636","source":"Crossref","is-referenced-by-count":10,"title":["Antibiotic Practice Patterns for Extremity Wound Infections among Blast-Injured Subjects"],"prefix":"10.1093","volume":"185","author":[{"given":"Laveta","family":"Stewart","sequence":"first","affiliation":[{"name":"Infectious Disease Clinical Research Program, Preventive Medicine & Biostatistics Department, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Drive, Suite 100, Bethesda, MD 20817"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"Infectious Disease Clinical Research Program, Preventive Medicine & Biostatistics Department, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814"},{"name":"The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., 6720A Rockledge Drive, Suite 100, Bethesda, MD 20817"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maj Dana M","family":"Blyth","sequence":"first","affiliation":[{"name":"Infectious Disease Service, Brooke Army Medical Center, 3551 Roger Brooke Drive #3600, Fort Sam Houston, TX 78234"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley R","family":"Campbell","sequence":"first","affiliation":[{"name":"Infectious Disease Service, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Bethesda, MD 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph L","family":"Petfield","sequence":"first","affiliation":[{"name":"Landstuhl Regional Medical Center, CMR 402, APO, AE, 19180, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Krauss","sequence":"first","affiliation":[{"name":"Westat, 1600 Research Boulevard, 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