{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:05:47Z","timestamp":1782183947139,"version":"3.54.5"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000182","name":"U.S. Army Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["W81XWH-14-1-0228"],"award-info":[{"award-number":["W81XWH-14-1-0228"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The peripheral auditory system and various structures within the central auditory system are vulnerable to blast injuries, and even blast overpressure is at relatively mild traumatic brain injury (TBI) level. However, the extent of hearing loss in relation to blast number and time course of post-blast is not well understood. This study reports the progressive hearing damage measured in chinchillas after multiple blast exposures at mild TBI levels (103\u2013138\u00a0kPa or 15\u201320\u00a0psi).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>Sixteen animals (two controls) were exposed to two blasts and three blasts, respectively, in two groups with both ears plugged with foam earplugs to prevent the eardrum from rupturing. Auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) were measured in pre- and post-blasts. Immunohistochemical study of chinchilla brains were performed at the end of experiment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Results show that the ABR threshold and DPOAE level shifts in 2-blast animals were recovered after 7\u00a0days. In 3-blast animals, the ABR and DPOAE shifts remained at 26 and 23\u00a0dB, respectively after 14\u00a0days. Variation of auditory cortex damage between 2-blast and 3-blast was also observed in immunofluorescence images.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study demonstrates that the number of blasts causing mild TBI critically affects hearing damage.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/milmed\/usz309","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T20:12:56Z","timestamp":1582143176000},"page":"248-255","source":"Crossref","is-referenced-by-count":20,"title":["Hearing Damage Induced by Blast Overpressure at Mild TBI Level in a Chinchilla Model"],"prefix":"10.1093","volume":"185","author":[{"given":"Kyle D","family":"Smith","sequence":"first","affiliation":[{"name":"School of Aerospace and Mechanical Engineering, University of Oklahoma, 865 Asp Avenue, Norman, OK 73019"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Aerospace and Mechanical Engineering, University of Oklahoma, 865 Asp Avenue, Norman, OK 73019"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong Z","family":"Gan","sequence":"additional","affiliation":[{"name":"School of Aerospace and Mechanical Engineering, University of Oklahoma, 865 Asp Avenue, Norman, OK 73019"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"issue":"74","key":"2021021901091793600_ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4103\/1463-1741.149574","article-title":"Hearing loss associated with US military combat deployment","volume":"17","author":"Wells","year":"2015","journal-title":"Noise 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