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The aim of this study was to compare 25 isolates of C. gattii from the Southeast region of Brazil with previously described isolates from other regions of the country and around the world. Among the 25 isolates, 24 were VGII and one was VGI. All of them were newly identified. Three new allele types (AT) (AT47 for the URA5 locus, AT56 for the LAC1 locus, and AT96 for the IGS1 region) were also described. Compared with other Brazilian isolates, those from the Southeast region presented the greatest haplotype diversity. In general, the regions presented different sequence types (STs), and only nine STs were found in more than one location. GoeBURST analysis showed two large groups among the Brazilian isolates. The largest group consists of 59 STs predominantly from the North and Northeast regions; the other large group includes 57 STs from the Southeast and Midwest regions. In a global context the South American isolates presented the highest genetic diversity (STs\u00a0=\u00a0145, haplotype diversity (Hd) = 0.999 and \u03c0 = 0.00464), while the African populations showed the lowest genetic diversity (STs\u00a0=\u00a03, Hd\u00a0=\u00a00.667 and \u03c0 = 0.00225). These results confirm that the Brazilian C. gattii VGII population is highly diverse and reinforce the hypothesis of dispersion of this genotype from South America.<\/jats:p>","DOI":"10.1093\/mmy\/myaa019","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T19:12:49Z","timestamp":1586805169000},"page":"1126-1137","source":"Crossref","is-referenced-by-count":16,"title":["High genetic variability of clinical and environmental Cryptococcus gattii isolates from Brazil"],"prefix":"10.1093","volume":"58","author":[{"given":"Anderson Man\u00e7an","family":"Vilas-B\u00f4as","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Internal Medicine Department, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-229X","authenticated-orcid":false,"given":"Leonardo 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Bragine","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Internal Medicine Department, Universidade Federal do Tri\u00e2ngulo Mineiro, Uberaba, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel de Assis","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aercio Sebasti\u00e3o","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Hospital de Cl\u00ednicas de Uberl\u00e2ndia, Uberl\u00e2ndia, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia de Souza Carvalho","family":"Melhem","sequence":"additional","affiliation":[{"name":"Mycology Department, Instituto Adolfo Lutz, S\u00e3o Paulo, S\u00e3o 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