{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:53:28Z","timestamp":1792004008027,"version":"4.4.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>Sporotrichosis, the most common subcutaneous mycosis in several countries, is caused by the dimorphic fungus, Sporothrix spp. Given some limitations in the treatment of this disease, and the high potential of nikkomycin Z (NikZ) as an antifungal against dimorphic fungi, this study aimed to evaluate the in vitro susceptibility of Sporothrix spp. to NikZ alone and with the drug of choice, itraconazole (ITZ). Seventeen clinical isolates of three Sporothrix spp. species (10 S. brasiliensis, six S. schenckii sensu stricto and one S. globosa) were tested in microdilution and checkerboard assays. Minimal inhibitory concentration (MIC), minimal fungicidal concentration (MFC), fractional inhibitory and fungicidal concentration indexes (FICi and FFCi) were analyzed. MIC of NikZ alone could be determined against S. globosa (12.5\u00a0\u03bcg\/ml) and against 67% (4\/6) and 30% (3\/10) of the S. schenckii sensu stricto and S. brasiliensis isolates, respectively (\u2264 400\u00a0\u03bcg\/ml). Synergism with ITZ was showed against almost all the isolates tested (94%; 16\/17), including reversing resistance to ITZ alone in some isolates. Our study shows the potential of NikZ in sporotrichosis treatment. Further studies in experimental models are needed to understand the possible future application of this drug as an alternative therapy or as an adjuvant in sporotrichosis treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Lay Abstract<\/jats:title>\n                  <jats:p>Sporotrichosis is a subcutaneous and lymphatic infection, caused by fungi of Sporothrix spp. Our study shows the potential of NikZ to inhibiting Sporothrix species in vitro. Further studies are needed to understand the future application of this drug to sporotrichosis treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mmy\/myaa054","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T03:21:37Z","timestamp":1591759297000},"page":"345-349","source":"Crossref","is-referenced-by-count":21,"title":["Potential use of Nikkomycin Z as an anti- <i>Sporothrix<\/i> spp. drug"],"prefix":"10.1093","volume":"59","author":[{"given":"Vanice Rodrigues","family":"Poester","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade , Faculdade de Medicina (FAMED), Universidade Federal do Rio Grande (FURG), RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Silveira","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade , Faculdade de Medicina (FAMED), Universidade Federal do Rio Grande (FURG), RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Larwood","sequence":"additional","affiliation":[{"name":"Valley Fever Solutions, Tucson, Arizona, USA"},{"name":"California Institute for Medical Research, San Jose, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marife","family":"Martinez","sequence":"additional","affiliation":[{"name":"California Institute for Medical Research, San Jose, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Stevens","sequence":"additional","affiliation":[{"name":"California Institute for Medical Research, San Jose, California, USA"},{"name":"Div. of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa 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