{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:20:24Z","timestamp":1793161224654,"version":"4.5.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100011701","name":"IAF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Malassezia restricta and Malassezia globosa are lipid dependent commensal yeasts associated with dandruff. Antifungal actives such as zinc pyrithione are commonly used in antidandruff shampoos, although their efficacy is not clearly demonstrated. In this study, we assessed the efficacy of antifungal treatments on scalp Malassezia via a combination of culturomic and genomic detection methods. Zinc pyrithione inhibited Malassezia growth at low minimum inhibitory concentrations (MICs). In a longitudinal pilot study, quantitative polymerase chain reaction (qPCR) analysis showed a decrease in M. restricta on the scalp after zinc pyrithione treatment. These findings validate the antifungal efficacy of zinc pyrithione as a dandruff treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Abstract<\/jats:title>\n                    <jats:p>Malassezia yeasts are associated with dandruff and seborrheic dermatitis. Zinc pyrithione is effective against Malassezia growth in vitro and when tested on human skin as a shampoo. These findings will be useful for investigating the role of Malassezia in skin microbiome intervention studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mmy\/myaa068","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T07:15:12Z","timestamp":1595488512000},"page":"210-213","source":"Crossref","is-referenced-by-count":26,"title":["Effect of zinc pyrithione shampoo treatment on skin commensal\n                    <i>Malassezia<\/i>"],"prefix":"10.1093","volume":"59","author":[{"given":"Cheryl","family":"Leong","sequence":"first","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Wang","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jet","family":"Toi","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuen In","family":"Lam","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joleen PZ","family":"Goh","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Mun","family":"Lee","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Thomas L","family":"Dawson","sequence":"additional","affiliation":[{"name":"Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"},{"name":"Center for Cell Death, Injury & Regeneration, Departments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"2021020323553387000_bib1","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1099\/mic.0.054528-0","article-title":"Purification and characterization of a secretory lipolytic enzyme, MgLIP2, from Malasseziaglobosa","volume":"157","author":"Juntachai","year":"2011","journal-title":"Microbiology."},{"key":"2021020323553387000_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1128\/CMR.00021-11","article-title":"The Malassezia genus in skin and systemic diseases","volume":"25","author":"Gaitanis","year":"2012","journal-title":"Clin Microbiol Rev."},{"key":"2021020323553387000_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/0019-5154.62734","article-title":"Dandruff: the most commercially exploited skin disease","volume":"55","author":"Ranganathan","year":"2010","journal-title":"Indian J Dermatol."},{"key":"2021020323553387000_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.jidsymp.5650049","article-title":"Malasseziaglobosa and restricta: breakthrough understanding of the etiology and treatment of dandruff and seborrheic dermatitis through whole-genome analysis","volume":"12","author":"Dawson","year":"2007","journal-title":"J Investig Dermatol Symp Proc."},{"key":"2021020323553387000_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00403-016-1623-1","article-title":"Exploration of scalp surface lipids reveals squalene peroxide as a potential actor in dandruff condition","volume":"308","author":"Jourdain","year":"2016","journal-title":"Arch Dermatol Res."},{"key":"2021020323553387000_bib6","first-page":"140","article-title":"Zinc pyrithione: a topical antimicrobial with complex pharmaceutics","volume":"15","author":"Schwartz","year":"2016","journal-title":"J. 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