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We performed in vitro broth microdilution assay of (PhSe)2\u00a0against 32 Aspergillus isolates; and a checkboard assay to test the interaction of this compound with itraconazole (ITC), voriconazole (VRC), amphotericin B (AMB), and caspofungin (CAS), against nine Aspergillus isolates. An experimental model of invasive aspergillosis in mice was studied, and survival curves were compared between an untreated group and groups treated with 100\u00a0mg\/kg ITC, or (PhSe)2 in different dosages (10\u00a0mg\/kg, 50\u00a0mg\/kg and 100\u00a0mg\/kg). All Aspergillus non-fumigatus and 50% of A. fumigatus were inhibited by (PhSe)2 in concentrations\u00a0\u2264\u00a064\u00a0\u00b5g\/ml, with significant differences in MICs between the sections. Synergism or additive effect in the in vitro (PhSe)2\u00a0interaction with VRC and CAS was observed against the majority of isolates, and with ITC against the non-fumigatus strains. In addition to the inhibitory interaction, (PhSe)2 was able to add a fungicidal effect to CAS. Survival curves from the systemic experimental aspergillosis model demonstrated that the inoculum caused an acute and lethal infection in mice, and no treatment applied significantly prolonged survival over that of the control group. The results highlight the promising activity of (PhSe)2 against Aspergillus species, but more in vivo studies are needed to determine its potential applicability in aspergillosis treatment.<\/jats:p>","DOI":"10.1093\/mmy\/myaa072","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T19:09:05Z","timestamp":1597950545000},"page":"528-536","source":"Crossref","is-referenced-by-count":17,"title":["Diphenyl diselenide and its interaction with antifungals against <i>Aspergillus<\/i> spp."],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-8715","authenticated-orcid":false,"given":"Aryse Martins","family":"Melo","sequence":"first","affiliation":[{"name":"Microbiology and Parasitology Post-graduation program, Institute of Biology, Federal University of Pelotas, Pelotas, RS, Brazil"},{"name":"Department of Infectious Diseases\/Reference Unit for Parasitic and Fungal Infections, National Institute of Health, Dr. Ricardo Jorge, Lisbon, Portugal"},{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanice Rodrigues","family":"Poester","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"},{"name":"Health Science Post-graduation program, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Trapaga","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Wayne","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Biological Sciences Post-graduation program, Department of Biochemistry and Molecular Biology, Center for Natural and Exact Sciences, Federal University of Santa Maria. 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