{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:26:09Z","timestamp":1740126369117,"version":"3.37.3"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We evaluated the growth and the susceptibility to oxidative stress of Sporothrix spp., exposed to different iron concentrations in culture medium, and the susceptibility of Sporothrix spp. to itraconazole, alone and in combination with to the iron chelator deferasirox. The results showed that the growth of S. brasiliensis isolates was more affected by iron availability in comparison to S. schenckii, but both fungal species conidia became more prone to oxidative stress when iron was added to culture medium. Conversely, the combination of itraconazole and deferasirox only resulted in synergism against a minority of S. schenckii isolates.<\/jats:p>","DOI":"10.1093\/mmy\/myaa099","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T21:41:51Z","timestamp":1606167711000},"page":"400-403","source":"Crossref","is-referenced-by-count":3,"title":["Influence of iron on growth and on susceptibility to itraconazole in <i>Sporothrix<\/i> spp"],"prefix":"10.1093","volume":"59","author":[{"given":"Alessandra Helena","family":"da Silva Hellwig","sequence":"first","affiliation":[{"name":"Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Machado","family":"Pagani","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Agricultural and Environmental Microbiology, UFRGS, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iasmin da Silva","family":"Rios","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, ICBS, UFRGS, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Carvalho","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, ICBS, UFRGS, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gis A","family":"Zanette","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biological Sciences: Pharmacology and Therapeutics, UFRGS, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L\u00facia","family":"Scroferneker","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brazil"},{"name":"Department of Microbiology, Immunology and Parasitology, ICBS, UFRGS, Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"2021040620582770500_bib1","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1093\/mmy\/myx103","article-title":"Sporotrichosis between 1898 and 2017: the evolution of knowledge on a changeable disease and on emerging etiological agents","volume":"56","author":"Lopes-Bezerra","year":"2018","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib2","first-page":"56","article-title":"Antifungal susceptibilities and identification of species of the Sporothrix schenckii complex isolated in Brazil","volume":"52","author":"Stopiglia","year":"2014","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/13693786.2010.539631","article-title":"Mycoses of implantation in Latin America: an overview of epidemiology, clinical manifestations, diagnosis and treatment","volume":"49","author":"Queiroz-Telles","year":"2011","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib4","first-page":"507","article-title":"Refractory sporotrichosis due to Sporothrix brasiliensis in humans appears to be unrelated to in vivo resistance","volume":"55","author":"Almeida-Paes","year":"2017","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib5","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/mmy\/myy163","article-title":"Prevalence and antifungal susceptibility of Sporothrix species in Jiangxi, central China","volume":"57","author":"Li","year":"2019","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.01057-17","article-title":"Multicenter and international study of MIC\/MEC distributions for definition of epidemiological cutoff values (ECVs) for species of Sporothrix identified by molecular methods","volume":"61","author":"Espinel-Ingroff","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2021040620582770500_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1590\/S0037-86822007000100012","article-title":"Suscetibilidade in vitro de isolados de Sporothrix schenckii frente \u00e0 terbinafina e itraconazol","volume":"40","author":"Meinerz","year":"2007","journal-title":"Rev Soc Bras Med Trop"},{"key":"2021040620582770500_bib8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/13693786.2012.669502","article-title":"Risk factors for mortality in patients with mucormycosis","volume":"50","author":"Spellberg","year":"2012","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib9","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1172\/JCI32338","article-title":"The iron chelator deferasirox protects mice from mucormycosis through iron starvation","volume":"117","author":"Ibrahim","year":"2007","journal-title":"J Clin Invest"},{"key":"2021040620582770500_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.imbio.2019.02.002","article-title":"Defective cytokine production from monocytes\/macrophages of E-beta thalassemia patients in response to Pythium insidiosum infection","volume":"224","author":"Ud-Naen","year":"2019","journal-title":"Immunobiology"},{"key":"2021040620582770500_bib11","doi-asserted-by":"crossref","first-page":"e0118932","DOI":"10.1371\/journal.pone.0118932","article-title":"Complex interaction of deferasirox and Pythium insidiosum: iron-dependent attenuation of growth in vitro and immunotherapy-like enhancement of immune responses in vivo","volume":"10","author":"Zanette","year":"2015","journal-title":"PLoS One"},{"key":"2021040620582770500_bib12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/mmy\/myy013","article-title":"Melanin: Quantification and protection against oxidative stress in chromoblastomycosis agents","volume":"57","author":"Heidrich","year":"2019","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib13","first-page":"52p","volume-title":"CLSI Document M38-A2","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"2021040620582770500_bib14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/AAC.00956-09","article-title":"Antifungal activity of colistin against Mucorales species in vitro and in a murine model of Rhizopus oryzae pulmonary infection","volume":"54","author":"Ben-Ami","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2021040620582770500_bib15","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/mmy\/myy042","article-title":"Galleria mellonella as a model system to study virulence potential of mucormycetes and evaluation of antifungal treatment","volume":"57","author":"Maurer","year":"2019","journal-title":"Med Mycol"},{"key":"2021040620582770500_bib16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijantimicag.2016.06.012","article-title":"Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus","volume":"48","author":"Lai","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"2021040620582770500_bib17","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1128\/AAC.49.9.3952-3954.2005","article-title":"In vitro antifungal susceptibilities of Sporothrix schenckii in two growth phases","volume":"49","author":"Trilles","year":"2005","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mmy\/article-pdf\/59\/4\/400\/36917914\/myaa099.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/mmy\/article-pdf\/59\/4\/400\/36917914\/myaa099.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:04:23Z","timestamp":1617753863000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/59\/4\/400\/6030114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,10]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12,10]]},"published-print":{"date-parts":[[2021,4,6]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myaa099","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"type":"print","value":"1369-3786"},{"type":"electronic","value":"1460-2709"}],"subject":[],"published-other":{"date-parts":[[2021,4]]},"published":{"date-parts":[[2020,12,10]]}}}