{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:38:44Z","timestamp":1790649524315,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"German Federal Ministry of Education and Health"},{"DOI":"10.13039\/501100013457","name":"Center for Sepsis Control and Care","doi-asserted-by":"publisher","award":["01E01002"],"award-info":[{"award-number":["01E01002"]}],"id":[{"id":"10.13039\/501100013457","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","award":["13GW0096D"],"award-info":[{"award-number":["13GW0096D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Activation of mucosal-associated invariant T cells (MAIT cells) by certain bacteria, viruses, and yeast is well studied, but the activation potential of filamentous moulds from the order Mucorales is not known. Here, we show a rapid response of human MAIT cells against the Mucorales species Mucor circinelloides, Rhizopus arrhizus, and Rhizopus microsporus. This activation included upregulation of CD69 and degranulation marked by increased CD107a expression, while intracellular perforin and granzyme A expression were reduced. Furthermore, blocking of the antigen-presenting molecule major histocompatibility complex class I-related abrogated MAIT cell activation demonstrating a T cell receptor-dependent stimulation by Mucorales.<\/jats:p>","DOI":"10.1093\/mmy\/myaa103","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T12:39:20Z","timestamp":1606826360000},"page":"505-509","source":"Crossref","is-referenced-by-count":5,"title":["Human mucosal-associated invariant T cells respond to Mucorales species in a MR1-dependent manner"],"prefix":"10.1093","volume":"59","author":[{"given":"Sarah","family":"B\u00f6ttcher","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Abteilung f\u00fcr H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"},{"name":"Infections in Hematology and Oncology, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Hartung","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Abteilung f\u00fcr H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"},{"name":"Infections in Hematology and Oncology, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Meyer","sequence":"additional","affiliation":[{"name":"Transfer Group Anti-infectives, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Rummler","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Transfusionsmedizin, Universit\u00e4tsklinikum Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Voigt","sequence":"additional","affiliation":[{"name":"Jena Microbial Resource Collection, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"},{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grit","family":"Walther","sequence":"additional","affiliation":[{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hochhaus","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Abteilung f\u00fcr H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"von Lilienfeld-Toal","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Abteilung f\u00fcr H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"},{"name":"Infections in Hematology and Oncology, Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"},{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz-Institute for Natural Product Research and Infection Biology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2609-3781","authenticated-orcid":false,"given":"Susanne","family":"Jahreis","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin II, Abteilung f\u00fcr H\u00e4matologie und Internistische Onkologie, Universit\u00e4tsklinikum Jena, Jena, Germany"},{"name":"Infections in 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