{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:15:50Z","timestamp":1793643350818,"version":"4.5.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Protection Research Unit"},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre for Antimicrobial Optimization"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>Prompt and reliable diagnosis of invasive pulmonary aspergillosis (IPA) is essential for early initiation of antifungal therapy. We evaluated bronchoalveolar lavage (BAL) fluid IMMY Sona Aspergillus lateral-flow assay (IMMY LFA) in 92 individuals with suspected pulmonary infection. Sensitivity and specificity (vs. host factor but no IPA) of BAL IMMY LFA for diagnosis of IPA in individuals with any European Organisation for Research and Treatment of Cancer-defied \u201chost factor\u201d were 67% and 85%, respectively. Performance appeared better in individuals with renal transplantation (100%, 100%), compared to those with hematological malignancy and\/or allogenic stem cell transplantation (70%, 78%). We found BAL IMMY LFA to be a convenient and useful addition to our diagnostic armory for IPA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Lay abstract<\/jats:title>\n                  <jats:p>We evaluated a new test for diagnosing invasive pulmonary aspergillosis from bronchoscopy samples. We tested 92 people and found that it was 67% sensitive and 85% specific (compared to diagnosis according to a set of internationally recognised criteria). We found this test convenient and useful.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mmy\/myaa113","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T20:12:57Z","timestamp":1609186377000},"page":"404-408","source":"Crossref","is-referenced-by-count":9,"title":["Bronchoalveolar lavage fluid IMMY Sona <i>Aspergillus<\/i> lateral-flow assay for the diagnosis of invasive pulmonary aspergillosis: a prospective, real life evaluation"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-2716","authenticated-orcid":false,"given":"P","family":"Arkell","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Imperial College Healthcare NHS Trust, London, United Kingdom"},{"name":"Department of Infectious Disease, Imperial College London, London, United Kingdom"},{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, W12 0NN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mahboobani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Imperial College London, London, United Kingdom"},{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, W12 0NN, United Kingdom"},{"name":"National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London. W12 0NN. United Kingdom"},{"name":"Pharmacy Department, Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Fatania","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, North West London Pathology (NWLP), Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Borman","sequence":"additional","affiliation":[{"name":"National Mycology Reference Laboratory, National Infections Service, Public Health England, Bristol BS10 5NB, United Kingdom"},{"name":"Medical Research Council Centre for Medical Mycology (MRC CMM), University of Exeter, Exeter EX4 4QD, United 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