{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:13:00Z","timestamp":1792725180024,"version":"4.5.0"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fungal infections are one of the most prevalent diseases in the world and there is a lack of new antifungal drug development for these diseases. We conducted a systematic review of the literature regarding the in vitro antifungal activity of the organoselenium compounds ebselen (Eb) and diphenyl diselenide [(PhSe)2]. A systematic review was carried out based on the search for articles with data concerning Minimal Inhibitory Concentration (MIC) values, indexed in international databases and published until August 2020. A total of 2337 articles were found, and, according to the inclusion and exclusion criteria used, 22 articles were included in the study. Inhibitory activity against 96% (200\/208) and 95% (312\/328) of the pathogenic fungi tested was described for Eb and [(PhSe)2], respectively. Including in these 536 fungal isolates tested, organoselenium activity was highlighted against Candida spp., Cryptococcus ssp., Trichosporon spp., Aspergillus spp., Fusarium spp., Pythium spp., and Sporothrix spp., with MIC values lower than 64\u00a0\u03bcg\/mL. In conclusion, Eb and [(PhSe)2] have a broad spectrum of in vitro inhibitory antifungal activity. These data added with other pharmacological properties of these organoselenium compounds suggest that both compounds are potential future antifungal drugs. Whether MICs toward the upper end of the ranges described here are compatible with efficacious therapy, and whether they may achieve such end as a result of the favorable non-antimicrobial effects of selenium on the host, requires more in vivo testing.<\/jats:p>","DOI":"10.1093\/mmy\/myaa115","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T07:54:02Z","timestamp":1608364442000},"page":"409-421","source":"Crossref","is-referenced-by-count":46,"title":["Ebselen and diphenyl diselenide against fungal pathogens: A systematic review"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-5349","authenticated-orcid":false,"given":"J\u00e9ssica Louise","family":"Benelli","sequence":"first","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"},{"name":"Health Science Post-graduation program, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanice Rodrigues","family":"Poester","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"},{"name":"Health Science Post-graduation program, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia Silveira","family":"Munhoz","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"},{"name":"Health Science Post-graduation program, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-8715","authenticated-orcid":false,"given":"Aryse Martins","family":"Melo","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"},{"name":"Microbiology and Parasitology Post-graduation program, Institute of Biology, Federal University of Pelotas, Pelotas, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Rodrigues","family":"Tr\u00e1paga","sequence":"additional","affiliation":[{"name":"Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Stevens","sequence":"additional","affiliation":[{"name":"California Institute for Medical Research, San Jose, California, USA"},{"name":"Division of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa 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