{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:01:02Z","timestamp":1776214862008,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["306330\/2018-0"],"award-info":[{"award-number":["306330\/2018-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2016\/03395-4"],"award-info":[{"award-number":["2016\/03395-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2016\/05226-5"],"award-info":[{"award-number":["2016\/05226-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Previous studies showed that the crude extract obtained from Streptococcus mutans inhibited the growth of Candida albicans reference strains. In this study, we evaluated whether the antifungal effects of S. mutans extract can be extended to clinical Candida isolates, including C. albicans and non-abicans strains with different susceptibilities to fluconazole. We verified that S. mutans extract increased the survival of Galleria mellonella larvae infected with C. albicans and C. glabrata and inhibited the fungal cells in hemolymph. These antifungal effects occurred for both fluconazole-susceptible and fluconazole-resistant strains. However, larvae infected by C. krusei were not affected by S. mutans extract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Streptococcus mutans crude extract shows antifungal effects on clinical Candida strains susceptible and resistant to fluconazole in Galleria mellonella model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mmy\/myab008","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T15:11:18Z","timestamp":1611673878000},"page":"744-747","source":"Crossref","is-referenced-by-count":1,"title":["Antifungal effects of\n                    <i>Streptococcus mutans<\/i>\n                    extract on\n                    <i>Candida<\/i>\n                    strains susceptible and resistant to fluconazole: An\n                    <i>in vivo<\/i>\n                    study"],"prefix":"10.1093","volume":"59","author":[{"given":"Mariana de S\u00e1","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP) , S\u00e3o Jos\u00e9 dos Campos, 12245-000, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Ruano de Oliveira","family":"Fugisaki","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP) , S\u00e3o Jos\u00e9 dos Campos, 12245-000, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Diane","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP) , S\u00e3o Jos\u00e9 dos Campos, 12245-000, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliana","family":"Scorzoni","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP) , S\u00e3o Jos\u00e9 dos Campos, 12245-000, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca Previate","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Institute of Chemistry, S\u00e3o Paulo State University (UNESP) , Araraquara, 14800-900, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce Helena Siqueira","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Institute of Chemistry, S\u00e3o Paulo State University (UNESP) , Araraquara, 14800-900, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Campos","family":"Junqueira","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, S\u00e3o Paulo State University (UNESP) , S\u00e3o Jos\u00e9 dos Campos, 12245-000, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"2026041420082331100_bib1","doi-asserted-by":"crossref","first-page":"e1006719","DOI":"10.1371\/journal.ppat.1006719","article-title":"The oral microbiome: a lesson in coexistence","volume":"14","author":"Sultan","year":"2018","journal-title":"PLoS Pathog."},{"key":"2026041420082331100_bib2","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1590\/S1517-83822011000400001","article-title":"Mutacins of Streptococcus mutans","volume":"42","author":"Kamiya","year":"2011","journal-title":"Braz J Microbiol."},{"key":"2026041420082331100_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0378-1119(01)00875-7","article-title":"Diversity of Streptococcus mutans bacteriocins as confirmed by DNA analysis using specific molecular probes","volume":"283","author":"Bekal-Si Ali","year":"2002","journal-title":"Gene"},{"key":"2026041420082331100_bib4","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/IAI.00087-14","article-title":"Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo","volume":"82","author":"Falsetta","year":"2014","journal-title":"Infect. 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