{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:50:45Z","timestamp":1788576645946,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>COVID-19-associated pulmonary aspergillosis (CAPA) incidence varies depending on the country. Serum galactomannan quantification is a promising diagnostic tool since samples are easy to obtain with low biosafety issues. A multicenter prospective study was performed to evaluate the CAPA incidence in Argentina and to assess the performance of the lateral flow assay with digital readout (S\u014dna Aspergillus LFA) as a CAPA diagnostic and screening tool. The correlation between the values obtained with S\u014dna Aspergillus LFA and Platelia\u00ae EIA was evaluated. In total, 578 serum samples were obtained from 185 critically ill COVID patients. CAPA screening was done weekly starting from the first week of ICU stay. Probable CAPA incidence in critically ill patients was 10.27% (19\/185 patients when LFA was used as mycological criteria) and 9% (9\/100 patients when EIA was used as mycological criteria). We found a very good correlation between the two evaluated galactomannan quantification methods (overall agreement of 92.16% with a Kappa statistic value of 0.721). CAPA diagnosis (&amp;gt;0.5 readouts in LFA) were done during the first week of ICU stay in 94.7% of the probable CAPA patients. The overall mortality was 36.21%. CAPA patients' mortality and length of ICU stay were not statistically different from for COVID (non-CAPA) patients (42.11 vs 33.13% and 29 vs 24 days, respectively). These indicators were lower than in other reports. LFA-IMMY with digital readout is a reliable tool for early diagnosis of CAPA using serum samples in critically ill COVID patients. It has a good agreement with Platelia\u00ae EIA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Lay Summary<\/jats:title>\n                  <jats:p>The incidence of COVID-associated pulmonary aspergillosis (CAPA) in critically-ill Argentinian patients was established (10.27%). Serum galactomannan quantification was useful as a screening tool for this mycosis. A good agreement between Platelia\u00ae EIA and S\u014dna Aspergillus LFA is reported.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mmy\/myac026","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T11:24:17Z","timestamp":1649417057000},"source":"Crossref","is-referenced-by-count":10,"title":["Usefulness of S\u014dna <i>Aspergillus<\/i> Galactomannan LFA with digital readout as diagnostic and as screening tool of COVID-19 associated pulmonary aspergillosis in critically ill patients. Data from a multicenter prospective study performed in Argentina"],"prefix":"10.1093","volume":"60","author":[{"given":"Gustavo","family":"Giusiano","sequence":"first","affiliation":[{"name":"Department of Micolog\u00eda, Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), H3500 Resistencia (Chaco), Argentina"},{"name":"Instituto de Medicina Regional, Universidad Nacional del Nordeste, H3500 Resistencia (Chaco). Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma B","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda, Divisi\u00f3n Infectolog\u00eda, Hospital de Cl\u00ednicas \u201c Jos\u00e9 de San Mart\u00edn\u201d Universidad de Buenos Aires, C1120AAF, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana G","family":"Vitale","sequence":"additional","affiliation":[{"name":"Department of Micolog\u00eda, Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), H3500 Resistencia (Chaco), Argentina"},{"name":"Unidad de Parasitolog\u00eda, Sector Micolog\u00eda, Hospital JM Ramos Mej\u00eda, C1221ADC Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Micolog\u00eda, \u2013 Laboratorio de Salud P\u00fablica de Tucum\u00e1n, San Miguel de Tucum\u00e1n, T4000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Ochiuzzi","sequence":"additional","affiliation":[{"name":"Hospital Durand, C1405DCS Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Santiso","sequence":"additional","affiliation":[{"name":"Centro de Estudios Micol\u00f3gicos, Ciudad Aut\u00f3noma de Buenos Aires, Argentina; Unidad Micolog\u00eda del Hospital de Infecciosas F. 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