{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:35:33Z","timestamp":1771259733228,"version":"3.50.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>This study aimed to characterize the baseline values and dynamics of serum (1,3)-Beta-D-Glucan (BDG) in neonates at high risk of neonatal invasive candidiasis (NIC); as well as to determine the effect of various clinical variables on these levels. Single center prospective cohort study was performed including 20 high-risk neonates (gestational age\u00a0&amp;lt;\u00a029 weeks and\/or birth weight\u00a0\u2264\u00a01000\u00a0gr). Samples for BDG (Fungitell\u00ae assay) were obtained twice weekly during 6 weeks. Nineteen neonates were enrolled with a median gestational age of 25 weeks (IQR 24\u201327), median birth weight of 730\u00a0gr (IQR 650\u2013810). None of the neonates was diagnosed with NIC. 190 serum samples were included. The median BDG value was 59\u00a0pg\/ml (IQR 30\u2013148), mean was 119 pg\/ml (SD\u00a0\u00b1\u00a0154). A total of 42.1% (80\/190) samples showed values\u00a0\u226580\u00a0pg\/ml, with all the neonates presenting at least one test above this cut-off. Neonatal age did not show an association with BDG levels. Exposure to steroids and the use of a heel prick as sampling method were associated with statistically significant higher BDG levels. The BDG levels showed high variability and in a significant proportion of samples values were above the threshold for positivity (e.g., \u226580\u00a0pg\/ml) in the absence of NIC. The exposure to postnatal steroids and the heel prick as the method of blood sampling were associated with higher BDG levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Lay Summary<\/jats:title>\n                  <jats:p>Neonatal invasive candidiasis (NIC) presents high morbi-mortality. The diagnosis of NIC is often challenging. Blood cultures have limitations and better diagnostic tools are needed. Beta-D-glucan is a diagnostic marker which could be potentially used, although still more clinical data are required.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mmy\/myac032","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T11:17:26Z","timestamp":1652181446000},"source":"Crossref","is-referenced-by-count":6,"title":["Serial (1\u20133)-beta-D-Glucan (BDG) monitoring shows high variability among premature neonates"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-1747","authenticated-orcid":false,"given":"Laura","family":"Ferreras-Antolin","sequence":"first","affiliation":[{"name":"St George's University Hospital NHS Foundation Trust , Paediatric Infectious Diseases Unit, London, United Kingdom"},{"name":"MRC Centre for Medical Mycology, University of Exeter , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasreen","family":"Aziz","sequence":"additional","affiliation":[{"name":"St. George's University Hospital NHS Foundation Trust , Neonatal Unit, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilia","family":"Warris","sequence":"additional","affiliation":[{"name":"MRC Centre for Medical Mycology, University of Exeter , United Kingdom"},{"name":"Great Ormond Street Hospital , Paediatric Infectious Diseases Unit, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"2022062909595341900_bib1","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/S0163-4453(17)30200-1","article-title":"Recognition and diagnosis of invasive fungal infections in neonates","volume":"74","author":"Calley","year":"2017","journal-title":"J 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