{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:24:03Z","timestamp":1778808243727,"version":"3.51.4"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["311470\/2018-1"],"award-info":[{"award-number":["311470\/2018-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","award":["E-26\/202.696\/2018"],"award-info":[{"award-number":["E-26\/202.696\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:label\/>\n                  <jats:p>Fungal infections have increased in the last years, particularly associated to an increment in the number of immunocompromised individuals and the emergence of known or new resistant species, despite the difficulties in the often time-consuming diagnosis. The controversial efficacy of the currently available strategies for their clinical management, apart from their high toxicity and severe side effects, has renewed the interest in the research and development of new broad antifungal alternatives. These encompass vaccines and passive immunization strategies with monoclonal antibodies (mAbs), recognizing ubiquitous fungal targets, such as fungal cell wall \u03b2-1,3-glucan polysaccharides, which could be used in early therapeutic intervention without the need for the diagnosis at species level. As additional alternatives, based on the Dectin-1 great affinity to \u03b2-1,3-glucan, our group developed broad antibody-like Dectin1-Fc(IgG)(s) from distinct subclasses (IgG2a and IgG2b) and compared their antifungal in vitro and passive immunizations in vivo performances. Dectin1-Fc(IgG2a) and Dectin1-Fc(IgG2b) demonstrated high affinity to laminarin and the fungal cell wall by ELISA, flow cytometry, and microscopy. Both Dectin-1-Fc(IgG)(s) inhibited Histoplasma capsulatum and Cryptococcus neoformans growth in a dose-dependent fashion. For Candida albicans, such inhibitory effect was observed with concentrations as low as 0.098 and 0.049\u00a0\u03bcg\/ml, respectively, which correlated with the impairment of the kinetics and lengths of germ tubes in comparison to controls. Previous opsonization with Dectin-1-Fc(IgG)(s) enhanced considerably the macrophage antifungal effector functions, increasing the fungi macrophages interactions and significantly reducing the intraphagosome fungal survival, as lower CFUs were observed. The administration of both Dectin1-Fc(IgG)(s) reduced the fungal burden and mortality in murine histoplasmosis and candidiasis models, in accordance with previous evaluations in aspergillosis model. These results altogether strongly suggested that therapeutic interventions with Dectin-1-Fc(IgG)(s) fusion proteins could directly impact the innate immunity and disease outcome in favor of the host, by direct neutralization, opsonization, phagocytosis, and fungal elimination, providing interesting information on the potential of these new strategies for the control of invasive fungal infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Lay Summary<\/jats:title>\n                  <jats:p>Mycoses have increased worldwide, and new efficient therapeutics are needed. Passive immunizations targeting universally the fungal cell would allow early interventions without the species-level diagnosis. Lectins with affinity to carbohydrates could be used to engineer \u2018antibody-like\u2019 strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mmy\/myac050","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T20:09:00Z","timestamp":1658520540000},"source":"Crossref","is-referenced-by-count":9,"title":["<i>In vitro<\/i> and <i>in vivo<\/i> efficacies of Dectin-1-Fc(IgG)(s) fusion proteins against invasive fungal infections"],"prefix":"10.1093","volume":"60","author":[{"given":"Susana","family":"Ruiz Mendoza","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Bioqu\u00edmica e Imunologia das Micoses, Instituto Biom\u00e9dico, Fluminense Federal University , 24020-150, Brazil"},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Imunologia e Inflama\u00e7\u00e3o, Federal University of Rio de Janeiro , 21941-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-6856","authenticated-orcid":false,"given":"Leonardo","family":"Nimrichter","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Glicobiologia de Eucariotos, Instituto de Microbiologia Paulo de G\u00f3es, Federal University of Rio de Janeiro , 21941-902, Brazil"},{"name":"Rede Micologia RJ \u2013 Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ) , RJ , 21914-902, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-4820","authenticated-orcid":false,"given":"Jos\u00e9 Mauro","family":"Peralta","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Diagn\u00f3stico Imunol\u00f3gico e Molecular de Doen\u00e7as Infecciosas e Parasit\u00e1rias, Federal University of Rio de Janeiro , 21941-902, 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