{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:36:45Z","timestamp":1776447405234,"version":"3.51.2"},"reference-count":161,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Aspergillus spp. osteoarticular infections are destructive opportunistic infections, while there is no clear consensus on their management. The purpose of this review is to investigate the current literature regarding Aspergillus spp. osteoarticular infections. An electronic search of the PubMed and Scopus databases was conducted considering studies that assessed osteoarticular infections from Aspergillus spp. We included only studies with biopsy proven documentation of positive cultures or histological findings for Aspergillus spp., and those with essential information for each case such as the anatomical location of the infection, the type of treatment (conservative, surgical, combination), the antifungal therapy, and the outcome. Overall, 148 studies from 1965 to 2021 including 186 patients were included in the review. One hundred and seven (57.5%) patients underwent surgical debridement in addition to antifungal therapy, while 79 (42.7%) patients were treated only conservatively. Complete infection resolution was reported in 107 (57.5%) patients, while partial resolution in 29 (15.5%) patients. Surgical debridement resulted in higher complete infection resolution rate compared to only antifungal therapy (70.0% vs. 40.5%, P\u00a0&amp;lt;\u00a00.001), while complete resolution rate was similar for antifungal monotherapy and combination\/sequential therapy (58.3% vs. 54.5%; P\u00a0=\u00a00.76). Last, complete resolution rate was also similar for monotherapy with amphotericin B (58.1%) and voriconazole (58.6%; P\u00a0=\u00a00.95). The results of this study indicate that antifungal monotherapy has similar efficacy with combination\/sequential therapy, while voriconazole has similar efficacy with amphotericin B. Moreover, surgical debridement of the infected focus results in better outcomes in terms of infection eradication compared to conservative treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Antifungal monotherapy has similar efficacy with combination\/sequential therapy, and voriconazole has similar efficacy with amphotericin B for the treatment of Aspergillus spp. osteoarticular infections, while surgical debridement of the infected focus improves the infection eradication rate.<\/jats:p><\/jats:sec>","DOI":"10.1093\/mmy\/myac052","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T20:09:06Z","timestamp":1658520546000},"source":"Crossref","is-referenced-by-count":14,"title":["<i>Aspergillus<\/i>spp. osteoarticular infections: an updated systematic review on the diagnosis, treatment and outcomes of 186 confirmed cases"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G","family":"Tsantes","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens , 15772 Athens , Greece"},{"name":"Department of Microbiology, \u2018Saint Savvas\u2019 Oncology Hospital , 11522 Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios V","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery , Geisinger Medical Center, Danville, PA 17821 , US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftheria","family":"Markou","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University Hospital of Ioannina , Ioannina 45500 , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Zarokostas","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u2018Saint Savvas\u2019 Oncology Hospital , 11522 Athens , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rozeta","family":"Sokou","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea , Piraeus 18454 , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Trikoupis","sequence":"additional","affiliation":[{"name":"First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine , Athens 15772 , Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas F","family":"Mavrogenis","sequence":"additional","affiliation":[{"name":"First Department of Orthopaedics, National and Kapodistrian University of Athens, 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