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Candida species and Streptococcus mutans were used to study this interaction due to their importance in oral health and disease as these microorganisms display a synergistic relationship that manifests in the onset of caries and tooth decay. Biofilms were developed in a 96-well microtiter plate at 37\u00baC for 24\u00a0h, under aerobiosis or microaerobic conditions, and treated with ozonated oil for 5 to 120\u00a0min. All the microorganisms formed biofilms in both oxygenation conditions. Scanning electron microscopy was used to visualize biofilm morphology. Rodent experiments were performed to verify the oil-related toxicity and its efficacy in oral candidiasis. The growth of all Candida species was increased when co-cultured with S. mutans, whilst the growth of bacterium was greater only when co-cultured with C. krusei and C. orthopsilosis under aerobiosis and microaerobic conditions, respectively. Regardless of the oxygenation condition, ozonated oil significantly reduced the viability of all the tested biofilms and infected mice, showing remarkable microbicidal activity as corroborated with confocal microscopy and minimal toxicity. Thus, ozonated oil therapy can be explored as a strategy to control diseases associated with these biofilms especially in the oral cavity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>We demonstrated that ozonated sunflower oil is effective at killing the biofilms formed by Candida species, by the bacterium Streptococcus mutans, or by both micoorganisms that can interact in the oral cavity, making it a potential therapeutic option for the treatment of these infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mmy\/myac055","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T11:00:32Z","timestamp":1658574032000},"source":"Crossref","is-referenced-by-count":16,"title":["Ozonated oil is effective at killing\n                    <i>Candida<\/i>\n                    species and\n                    <i>Streptococcus mutans<\/i>\n                    biofilm-derived cells under aerobic and microaerobic conditions"],"prefix":"10.1093","volume":"60","author":[{"given":"Barbara","family":"Higa","sequence":"first","affiliation":[{"name":"Laboratory of Mycology and Environmental Diagnosis, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Souza","family":"Cintra","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology and Environmental Diagnosis, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]},{"name":"Postgraduate Program in Animal Science, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Magaly","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology and Environmental Diagnosis, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]},{"name":"Faculty of Veterinary Medicine and Zootechnics, Universidad Agraria del Ecuador , Guayaquil 090101,","place":["Ecuador"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Barcelos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Mutagenesis Laboratory, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-3463","authenticated-orcid":false,"given":"Jair Camargo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Animal Science, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-5914","authenticated-orcid":false,"given":"Denise Crispim","family":"Tavares","sequence":"additional","affiliation":[{"name":"Mutagenesis Laboratory, Universidade de Franca , Franca, S\u00e3o Paulo 14.404-600,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Enriquez","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, College of Dentistry, University of Florida , Gainesville, Florida 32610,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6372-6501","authenticated-orcid":false,"given":"Luis R","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, College of Dentistry, University of Florida , Gainesville, Florida 32610,","place":["USA"]},{"name":"Emerging Pathogens Institute, Center for Immunology and Transplantation, and Center for Translational Research in Neurodegenerative Disease, University of Florida , Gainesville, Florida 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