{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:06:13Z","timestamp":1753877173657,"version":"3.41.2"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671182"],"award-info":[{"award-number":["81671182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313228"],"award-info":[{"award-number":["2016A030313228"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To explore the brain volume (BV) changes of HIV-negative and non-transplant cryptococcal meningitis (CM) in 1 year after initial therapy. Case data were collected from 78 CM patients who underwent magnetic resonance imaging (MRI) scanning at least 3 times in 1-year interval after initial therapy. The assessment of BV was measured by a non-commercial software, uAI Research Portal. Linear mixed model was used to investigate the association between clinical characteristics and the changes in BV. Longitudinal study showed a decrease in total brain volume (\u22124.65 cm3, P\u00a0=\u00a0.005), regional brain volume including white matter (\u22122.86 cm3, P\u00a0=\u00a0.031) and basal ganglia (\u22120.25 cm3, P\u00a0=\u00a0.007), and increase in cerebrospinal fluid (CSF) volume (3.58 cm3, P\u00a0=\u00a0.013) in CM patients in 1 year after initial therapy. Ventricular volume in patients with ventriculoperitoneal shunts (VPS) was lower than that in patients without VPS (\u22127.5 cm3, P\u00a0&amp;lt;\u00a0.05). Ventricular volume in patients with post-infectious inflammatory response syndrome (PIIRS) was larger than that in patients without PIIRS (7.1 cm3, P\u00a0&amp;lt;\u00a0.01). In addition, temporal lobe atrophy was associated with corticosteroid therapy (\u22126.8 cm3, P\u00a0&amp;lt;\u00a0.01). The present study suggested that brain atrophy, especially regional BV decrease, could happen in HIV-negative and non-transplant CM patients over a 1-year interval.<\/jats:p>","DOI":"10.1093\/mmy\/myac068","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T14:31:22Z","timestamp":1662647482000},"source":"Crossref","is-referenced-by-count":0,"title":["The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9822-5184","authenticated-orcid":false,"given":"Bang-e","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , 600# Tianhe Road, Guangzhou, Guangdong 510630, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Affiliated Hospital of 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