{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:19:58Z","timestamp":1791958798308,"version":"4.3.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From March 2013 to January 2019, a descriptive prospective study on CBM patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200\u00a0mg was given to patients every day for \u02c33 months. Results were assessed at the 6th and 12th months and classified as major responses, minor responses to treatment, or failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 29 cases of CBM were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow-up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared with CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings demonstrated that CBM lesions are recalcitrant and difficult to treat.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mmy\/myac086","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T17:27:36Z","timestamp":1666805256000},"source":"Crossref","is-referenced-by-count":10,"title":["Treatment responses in patients with chromoblastomycosis to itraconazole in Madagascar"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2606-3539","authenticated-orcid":false,"given":"Fandresena Arilala","family":"Sendrasoa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Antananarivo , Antananarivo 101, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volatantely Tobiniaina","family":"Ratovonjanahary","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Antananarivo , Antananarivo 101, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahinamandranto","family":"Rasamoelina","sequence":"additional","affiliation":[{"name":"Centre d'Infectiologie Charles M\u00e9rieux, University of Antananarivo , Antananarivo 101, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lala Soavina","family":"Ramarozatovo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Antananarivo , Antananarivo 101, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahafahantsoa","family":"Rapelanoro Rabenja","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, 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