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We evaluated canine sporotrichosis's clinical-therapeutic, epidemiological profile, and in vitro susceptibility of isolates to itraconazole. The variables were evaluated by a chi-square test. A total of 69 dogs were infected with Sporothrix spp., and the molecular identification revealed an overwhelming occurrence of S. brasiliensis as the etiological agent. The epidemiological profile was male (56.5%), adults (4.9\u00a0\u00b1\u00a01.92 years old; 69.6%), and mongrels (53.6%). The clinical signs were 76.8%, ulcers, draining tracts, and nodules were predominant, mainly in the nasal region (82.2%). Dogs were diagnosed late with an evolution time of up to 3 months (34.8%). According to the prior therapeutic information, 52.2% received empirical therapy, 79.2% antibiotics, and had a 0.29 significantly greater chance of presenting lesion evolution time \u02c3 3 months (P\u00a0&amp;lt;\u00a0.05; Odds Ratio [OR] 1\/0.29). Additionally, 25 S. brasiliensis isolates recovered between 2006\u20132012 (n\u00a0=\u00a015; Minimal inhibitory concentration (MIC): 0.06\u20132\u00a0\u03bcg\/ml) and 2013\u20132018 (n\u00a0=\u00a010; MIC: 2\u219216\u00a0\u03bcg\/ml) were tested against itraconazole (ITZ). These findings highlighted the resistance to ITZ in clinical cases due to S. brasiliensis occurring after 2013, showing the temporal evolution of ITZ-resistance. We warn of the importance of accurate and early diagnosis in Sporothrix-affected areas, and we report the emergence of ITZ-resistant isolates in Southern Brazil.<\/jats:p>","DOI":"10.1093\/mmy\/myac089","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T07:25:32Z","timestamp":1669965932000},"source":"Crossref","is-referenced-by-count":12,"title":["Sporotrichosis in dogs: epidemiological and clinical-therapeutic profile and the emergence of itraconazole-resistant isolates"],"prefix":"10.1093","volume":"60","author":[{"given":"Sergiane","family":"Baes Pereira","sequence":"first","affiliation":[{"name":"Department of Preventive Veterinary, Faculty of Veterinary, Federal University of Pelotas , Pelotas , RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-044X","authenticated-orcid":false,"given":"Angelita","family":"dos Reis Gomes","sequence":"additional","affiliation":[{"name":"Veterinary Mycology Diagnostic and Research Center, Faculty of Veterinary, Federal University of Pelotas , Pelotas, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6719-1794","authenticated-orcid":false,"given":"Stefanie","family":"Bressan Waller","sequence":"additional","affiliation":[{"name":"Veterinary Mycology Diagnostic and Research Center, Faculty of Veterinary, Federal University of Pelotas , Pelotas, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-3108","authenticated-orcid":false,"given":"Jose Raphael","family":"Batista Xavier","sequence":"additional","affiliation":[{"name":"Veterinary Mycology Diagnostic and Research Center, Faculty of Veterinary, Federal University of Pelotas , Pelotas, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Messias Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Fungal Pathogens, Department of Microbiology, Immunology, and Parasitology, Federal University of S\u00e3o Paulo (UNIFESP) , S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"Kutscher Ripoll","sequence":"additional","affiliation":[{"name":"Veterinary Mycology Diagnostic and Research Center, Faculty of Veterinary, Federal University of Pelotas , Pelotas, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Roberto Alves","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Technological Development Center, Faculty of Biotechnology, Federal University of Pelotas , Pelotas, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Rochedo Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Technological Development Center, Faculty of Biotechnology, Federal University of Pelotas , Pelotas, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Os\u00f3rio de Faria","sequence":"additional","affiliation":[{"name":"Department of Preventive Veterinary, Faculty of Veterinary, Federal University of Pelotas , Pelotas , RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Raphael","family":"Pascoti Bruhn","sequence":"additional","affiliation":[{"name":"Department of Preventive Veterinary, Faculty of Veterinary, Federal University of Pelotas , Pelotas , RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2022121515102279600_bib1","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1590\/S0102-311X2012001000006","article-title":"Urban sporotrichosis: a neglected epidemic in Rio de Janeiro, Brazil","volume":"28","author":"Silva","year":"2012","journal-title":"Cad. 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