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Immunocompetent Wistar rats were divided into two groups (n\u00a0=\u00a035): Tetracycline\u00a0=\u00a0administration of 0.83\u00a0mg\/ml of tetracycline hydrochloride 7 days before induction of denture stomatitis and amoxicillin\u00a0=\u00a0administration of 0.156\u00a0mg\/ml of amoxicillin with clavulanic acid 4 days before induction of denture stomatitis. A suspension of Candida albicans was inoculated on the palate followed by the use of a palatal device contaminated with C. albicans inoculum for 4 days to induce denture stomatitis. As controls, some rats were not submitted to any procedure or used a sterile palatal device for 4 days. The development of denture stomatitis was confirmed by visual analysis, colony-forming units per milliliter (CFU\/ml) count, histopathological and immunohistochemical analyses, and through myeloperoxidase (MPO) and N-acetylglucosaminidase (NAG) assays. Rats were euthanized right after device removal (T0), 4 (T4), or 6 (T6) days after device removal. Tetracycline improved the development of the disease, with more severe clinical signs at T0. Similar results were observed in the CFU\/ml count and in the histometric and immunohistochemical analyses. Higher MPO expression was detected in the palates of the tetracycline group (P\u00a0=\u00a0.006). Despite the subtle differences between antibiotics, tetracycline showed better results in inducing and maintaining denture stomatitis for at least 4 days after device removal.<\/jats:p>","DOI":"10.1093\/mmy\/myac092","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T18:17:21Z","timestamp":1669400241000},"source":"Crossref","is-referenced-by-count":7,"title":["A novel rat model of denture stomatitis and the role of antibiotics in the development of the disease"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0777-5012","authenticated-orcid":false,"given":"Gustavo Sim\u00e3o","family":"Moraes","sequence":"first","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds","family":"Albach","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Yoshi Campos","family":"Sugio","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of S\u00e3o Paulo , Bauru ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria Schlumberger","family":"Cachoeira","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falyne","family":"Kiratcz","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Claudino","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Bauml","family":"Campagnoli","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Tha\u00eds","family":"Pochapski","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Andr\u00e9","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Hermana","family":"Neppelenbroek","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of S\u00e3o Paulo , Bauru ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Migliorini","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Dentistry, State University of Ponta Grossa , Ponta Grossa ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"2026041420083039700_bib1","doi-asserted-by":"crossref","first-page":"E380","DOI":"10.1111\/j.1469-0691.2012.03933.x","article-title":"Comparison of photodynamic therapy versus conventional antifungal therapy for the treatment of denture stomatitis: A randomized clinical trial","volume":"18","author":"Mima","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2026041420083039700_bib2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1834-7819.1998.tb00172.x","article-title":"Candida-associated denture stomatitis. 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