{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:08:35Z","timestamp":1753877315055,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"MRC Center for Medical Mycology","award":["MR\/N006364\/2"],"award-info":[{"award-number":["MR\/N006364\/2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The indications for nystatin as prophylaxis or treatment are limited. In the PASOAP (Pediatric Antifungal Stewardship Optimizing Antifungal Prescription) study, high use of nystatin in hospitalized children beyond the neonatal age was observed. In this report, we present the data on nystatin use in infants and children\u00a0\u2265\u00a03 months who participated in the PASOAP study. Nystatin was prescribed mainly for prophylaxis. Congenital heart disease, cystic fibrosis, and chronic renal disease were the most commonly reported conditions in children receiving prophylactic nystatin. There is sparse evidence supporting the use of nystatin prophylaxis beyond neonates; trials in specific pediatric patient groups are required.<\/jats:p>","DOI":"10.1093\/mmy\/myac097","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T01:16:41Z","timestamp":1673140601000},"source":"Crossref","is-referenced-by-count":0,"title":["Nystatin is commonly prescribed as prophylaxis in children beyond the neonatal age"],"prefix":"10.1093","volume":"61","author":[{"given":"Harshani","family":"Jayawardena-Thabrew","sequence":"first","affiliation":[{"name":"Medical Research Council Center for Medical Mycology, University of Exeter , Exeter , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilia","family":"Warris","sequence":"additional","affiliation":[{"name":"Medical Research Council Center for Medical Mycology, University of Exeter , Exeter , United Kingdom"},{"name":"Department of Pediatric Infectious Diseases, Great Ormond Street Hospital for Children , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The PASOAP Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-1747","authenticated-orcid":false,"given":"Laura","family":"Ferreras-Antolin","sequence":"additional","affiliation":[{"name":"Medical Research Council Center for Medical Mycology, University of Exeter , Exeter , United Kingdom"},{"name":"Pediatric Infectious Diseases and Immunology Unit, St George's University Hospitals, NHS Foundation Trust , London , United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"2023010908223925500_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof6040321","article-title":"Amphotericin B and other polyenes\u2014discovery, clinical use, mode of action and drug resistance","volume":"6","author":"Carolus","year":"2020","journal-title":"J Fungi"},{"key":"2023010908223925500_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical practice guideline for the management of Candidiasis\u202f: 2016 update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2023010908223925500_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/1469-0691.12040","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012\u202f: Prevention and management of invasive infections in neonates and children caused by Candida spp","volume":"18","author":"Hope","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2023010908223925500_bib4","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1097\/INF.0000000000002463","article-title":"Neonatal antifungal consumption is dominated by prophylactic use; outcomes from the  pediatric antifungal stewardship","volume":"38","author":"Ferreras-Antol\u00edn","year":"2019","journal-title":"Pediatr Infect Dis J"},{"key":"2023010908223925500_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/INF.0000000000003402","article-title":"Pediatric antifungal prescribing patterns identify significant opportunities to rationalize antifungal use in children","volume":"41","author":"Ferreras-Antol\u00edn","year":"2022","journal-title":"Pediatr Infect Dis J"},{"key":"2023010908223925500_bib6","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1186\/cc11300","article-title":"Oral nystatin prophylaxis in surgical\/trauma ICU patients: A randomised clinical trial","volume":"16","author":"Giglio","year":"2012","journal-title":"Crit Care"},{"key":"2023010908223925500_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2110-5820-2-6","article-title":"Invasive fungal disease in PICU\u202f: epidemiology and risk factors","volume":"2","author":"Brissaud","year":"2012","journal-title":"Ann Intensive Care"},{"key":"2023010908223925500_bib8","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1097\/01.CCM.0000181726.32675.37","article-title":"The use of topical nonabsorbable gastrointestinal antifungal prophylaxis to prevent fungal infections in critically ill immunocompetent patients: A meta-analysis","volume":"33","author":"Ho","year":"2005","journal-title":"Crit Care Med"},{"key":"2023010908223925500_bib9","article-title":"Antifungal agents for preventing fungal infections in non-neutropenic critically ill patients","volume":"2016","author":"Cortegiani","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2023010908223925500_bib10","first-page":"159","article-title":"Evaluation of Candida colonization and use of the Candida colonization index in a pediatric intensive care unit: A prospective observational study","volume":"27","author":"Altintop","year":"2019","journal-title":"Infez Med"},{"key":"2023010908223925500_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/01.PCC.0000298643.48547.83","article-title":"Candida colonization and candidemia in a pediatric intensive care unit","volume":"9","author":"Singhi","year":"2008","journal-title":"Pediatr Crit Care Med"},{"key":"2023010908223925500_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/icvts\/ivw156","article-title":"Fungal infections in children in the early postoperative period after cardiac surgery for congenital heart disease: A single-center experience","volume":"23","author":"Jaworski","year":"2016","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2023010908223925500_bib13","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/INF.0000000000003005","article-title":"Invasive bacterial and fungal infections after pediatric cardiac surgery: A single-center experience","volume":"40","author":"T\u00f6nz","year":"2021","journal-title":"Pediatr Infect Dis J"},{"key":"2023010908223925500_bib14","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/myc.12680","article-title":"Role of oral nystatin prophylaxis in cardiac surgery with prolongedextracorporeal circulation","volume":"60","author":"Russo","year":"2017","journal-title":"Mycoses"},{"key":"2023010908223925500_bib15","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.3390\/jcm10163725","article-title":"New insights in microbial species predicting lung function decline in CF: Lessons from the MucoFong Project","volume":"10","author":"Francis","year":"2021","journal-title":"J Clin Med"},{"key":"2023010908223925500_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11046-017-0182-0","article-title":"Progress in definition, prevention and treatment of fungal infections in cystic fibrosis","volume":"183","author":"Schwarz","year":"2018","journal-title":"Mycopathologia"},{"key":"2023010908223925500_bib17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.5301\/ijao.5000219","article-title":"Long-term peritoneal dialysis experience: Quality control supports the use of fluconazole to prevent fungal peritonitis","volume":"36","author":"Lopes","year":"2013","journal-title":"Int J Artif Organs"},{"key":"2023010908223925500_bib18","first-page":"1","article-title":"Antifungal agents for preventing fungal infections in solid organ transplant recipients (Review)","author":"Playford","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"2023010908223925500_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ctr.13623","article-title":"Candida infections in solid organ transplantation: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Aslam","year":"2019","journal-title":"Clin Transplant"},{"key":"2023010908223925500_bib20","doi-asserted-by":"crossref","first-page":"II16","DOI":"10.1093\/jac\/dkz039","article-title":"Defining standards of CARE for invasive fungal diseases in solid organ transplant patients","volume":"74","author":"Garcia-Vidal","year":"2019","journal-title":"J Antimicrob Chemother"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myac097\/48500172\/myac097.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/61\/1\/myac097\/48555038\/myac097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/61\/1\/myac097\/48555038\/myac097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T08:25:07Z","timestamp":1673252707000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myac097\/6969424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,29]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myac097","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"type":"print","value":"1369-3786"},{"type":"electronic","value":"1460-2709"}],"subject":[],"published-other":{"date-parts":[[2023,1]]},"published":{"date-parts":[[2022,12,29]]},"article-number":"myac097"}}