{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:12:59Z","timestamp":1793711579423,"version":"4.6.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In spite of the increasing medical interest in Malassezia yeasts, the virulence factors of Malassezia furfur causing bloodstream infections (BSI) were never investigated. Therefore, phospholipase (Pz), lipase (Lz), hemolysin (Hz), biofilm production, and in vitro antifungal susceptibility profiles were evaluated in M. furfur strains, isolated from both pityriasis versicolor (PV) patients (n\u00a0=\u00a018; Group 1) or from preterm infants BSI (n\u00a0=\u00a021; Group 2). All the test stains exhibited Pz activity, whereas 92.3% and 97.4% of strains exhibited Lz and Hz activities, respectively. Pz, Lz, and Hz activities were higher (i.e., lower values) within Group 1 strains (i.e., 0.48, 0.40, and 0.77) than those within Group 2 (i.e., 0.54, 0.54, and 0.81). The biofilm production was higher within Malassezia isolates from Group 2 (0.95\u00a0\u00b1\u00a00.3) than from Group 1 (0.72\u00a0\u00b1\u00a00.4). Itraconazole and posaconazole were the most active drugs against M. furfur, followed by amphotericin B and fluconazole. The minimum inhibitory concentrations (MIC) values varied according to the origin of M. furfur strains being statistically lower in M. furfur from Group 1 than from Group 2. This study suggests that M. furfur strains produce hydrolytic enzymes and biofilm when causing PV and BSI. Data show that the phospholipase activity, biofilm production, and a reduced antifungal susceptibility profile might favor M. furfur BSI, whereas lipase and hemolytic activities might display a synergic role in skin infection.<\/jats:p>","DOI":"10.1093\/mmy\/myad003","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T23:56:30Z","timestamp":1673394990000},"source":"Crossref","is-referenced-by-count":8,"title":["Comparison of virulence factors and susceptibility profiles of <i>Malassezia furfur<\/i> from pityriasis versicolor patients and bloodstream infections of preterm infants"],"prefix":"10.1093","volume":"61","author":[{"given":"Wafa","family":"Rhimi","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Veterinaria , Universit\u00e0 degli Studi \u201cAldo Moro\u201d, Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissal","family":"Chebil","sequence":"additional","affiliation":[{"name":"Laboratory of 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Universit\u00e0 degli Studi \u201cAldo Moro\u201d, Bari , Italy"},{"name":"Department of Pathobiology, Faculty of Veterinary Sciences, Bu-Ali Sina University , Hamedan , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-4472","authenticated-orcid":false,"given":"Claudia","family":"Cafarchia","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria , Universit\u00e0 degli Studi \u201cAldo Moro\u201d, Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"2023013010390648300_bib1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/mmycol\/myu016","article-title":"Uncommon opportunistic yeast bloodstream infections from Qatar","volume":"52","author":"Taj-Aldeen","year":"2014","journal-title":"Med 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