{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:14:25Z","timestamp":1792638865758,"version":"4.5.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T00:00:00Z","timestamp":1674864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["106-2923-B-002-001-MY3"],"award-info":[{"award-number":["106-2923-B-002-001-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["107-2320-B-002-061-MY3"],"award-info":[{"award-number":["107-2320-B-002-061-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2923-B-002-002-MY3"],"award-info":[{"award-number":["110-2923-B-002-002-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2320-B-002-050-MY3"],"award-info":[{"award-number":["110-2320-B-002-050-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2320-B-005-001-MY2"],"award-info":[{"award-number":["110-2320-B-005-001-MY2"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida glabrata is an opportunistic fungal pathogen and the second most prevalent species isolated from candidiasis patients. C. glabrata has intrinsic tolerance to antifungal drugs and oxidative stresses and the ability to adhere to mucocutaneous surfaces. However, knowledge about the regulation of its virulence traits is limited. The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex modulates gene transcription by histone acetylation through the histone acetyltransferase (HAT) module comprised of Gcn5-Ada2-Ada3. Previously, we showed that the ada2 mutant was hypervirulent but displayed decreased tolerance to antifungal drugs and cell wall perturbing agents. In this study, we further characterized the functions of Ada3 and Gcn5 in C. glabrata. We found that single, double, or triple deletions of the HAT module, as expected, resulted in a decreased level of acetylation on histone H3 lysine 9 (H3K9) and defective growth. These mutants were more susceptible to antifungal drugs, oxidative stresses, and cell wall perturbing agents compared with the wild-type. In addition, HAT module mutants exhibited enhanced agar invasion and upregulation of adhesin and proteases encoding genes, whereas the biofilm formation of those mutants was impaired. Interestingly, HAT module mutants exhibited enhanced induction of catalases (CTA1) expression upon treatment with H2O2 compared with the wild-type. Lastly, although ada3 and gcn5 exhibited marginal hypervirulence, the HAT double and triple mutants were hypervirulent in a murine model of candidiasis. In conclusion, the HAT module of the SAGA complex plays unique roles in H3K9 acetylation, drug tolerance, oxidative stress response, adherence, and virulence in C. glabrata.<\/jats:p>","DOI":"10.1093\/mmy\/myad004","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T11:21:41Z","timestamp":1675077701000},"source":"Crossref","is-referenced-by-count":8,"title":["The Gcn5-Ada2-Ada3 histone acetyltransferase module has divergent roles in pathogenesis of <i>Candida glabrata<\/i>"],"prefix":"10.1093","volume":"61","author":[{"given":"Chi-Jan","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology, National Chung Hsing University , 40227 Taichung , Taiwan"},{"name":"Department of Plant Pathology and Microbiology, National Taiwan University , 10617 Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Yung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, National Taiwan University , 10617 Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, National Taiwan University , 10617 Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, National Taiwan University , 10617 Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-470X","authenticated-orcid":false,"given":"Ying-Lien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, National Taiwan University , 10617 Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,28]]},"reference":[{"key":"2023020312503360500_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijantimicag.2013.09.005","article-title":"Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities","volume":"43","author":"Wisplinghoff","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"2023020312503360500_bib2","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Trans Med"},{"key":"2023020312503360500_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"2023020312503360500_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.diagmicrobio.2009.03.007","article-title":"Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection","volume":"64","author":"Klevay","year":"2009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2023020312503360500_bib5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tim.2011.02.003","article-title":"Adherence and biofilm formation of non-Candida albicans Candida species","volume":"19","author":"Silva","year":"2011","journal-title":"Trends Microbiol"},{"key":"2023020312503360500_bib6","doi-asserted-by":"crossref","first-page":"e0120452","DOI":"10.1371\/journal.pone.0120452","article-title":"Declining incidence of candidemia and the shifting epidemiology of Candida resistance in two US metropolitan areas, 2008-2013: results from population-based surveillance","volume":"10","author":"Cleveland","year":"2015","journal-title":"PLoS One"},{"key":"2023020312503360500_bib7","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s15010-020-01475-8","article-title":"Emerging echinocandin-resistant Candida albicans and glabrata in Switzerland","volume":"48","author":"Coste","year":"2020","journal-title":"Infection"},{"key":"2023020312503360500_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/21505594.2016.1257457","article-title":"New facets of antifungal therapy","volume":"8","author":"Chang","year":"2017","journal-title":"Virulence"},{"key":"2023020312503360500_bib9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092345","article-title":"Divergent approaches to virulence in C. albicans and C. glabrata: two sides of the same coin","volume":"20","author":"Galocha","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2023020312503360500_bib10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.15698\/mic2019.03.670","article-title":"Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection","volume":"6","author":"Pais","year":"2019","journal-title":"Microb Cell"},{"key":"2023020312503360500_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.18869\/acadpub.cmm.2.4.49","article-title":"Pseudohyphae formation in Candida glabrata due to CO2 exposure","volume":"2","author":"Sasani","year":"2016","journal-title":"Curr Med Mycol"},{"key":"2023020312503360500_bib12","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7020039","article-title":"Candida glabrata: a lot more than meets the eye","volume":"7","author":"Kumar","year":"2019","journal-title":"Microorganisms"},{"key":"2023020312503360500_bib13","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.riam.2013.09.012","article-title":"The oxidative stress response of the opportunistic fungal pathogen Candida glabrata","volume":"31","author":"Briones-Martin-Del-Campo","year":"2014","journal-title":"Rev Iberoam Micol"},{"key":"2023020312503360500_bib14","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1128\/EC.00011-08","article-title":"High resistance to oxidative stress in the fungal pathogen Candida glabrata is mediated by a single catalase","volume":"7","author":"Cuellar-Cruz","year":"2008","journal-title":"Eukaryot Cell"},{"key":"2023020312503360500_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.febslet.2010.12.006","article-title":"Regulation of Candida glabrata oxidative stress resistance is adapted to host environment","volume":"585","author":"Roetzer","year":"2011","journal-title":"FEBS Lett"},{"key":"2023020312503360500_bib16","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1099\/mic.0.000006","article-title":"The superoxide dismutases of Candida glabrata protect against oxidative damage and are required for lysine biosynthesis, DNA integrity and chronological life survival","volume":"161","author":"Briones-Martin-Del-Campo","year":"2015","journal-title":"Microbiology (Reading)"},{"key":"2023020312503360500_bib17","doi-asserted-by":"crossref","first-page":"103287","DOI":"10.1016\/j.fgb.2019.103287","article-title":"Candida glabrata peroxiredoxins, Tsa1 and Tsa2, and sulfiredoxin, Srx1, protect against oxidative damage and are necessary for virulence","volume":"135","author":"Gutierrez-Escobedo","year":"2020","journal-title":"Fungal Genet Biol"},{"key":"2023020312503360500_bib18","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0092-8674(00)81063-6","article-title":"Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation","volume":"84","author":"Brownell","year":"1996","journal-title":"Cell"},{"key":"2023020312503360500_bib19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ceb.2010.03.005","article-title":"Multiple faces of the SAGA complex","volume":"22","author":"Koutelou","year":"2010","journal-title":"Curr Opin Cell Biol"},{"key":"2023020312503360500_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13072-021-00402-x","article-title":"Conservation and diversity of the eukaryotic SAGA coactivator complex across kingdoms","volume":"14","author":"Chen","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"2023020312503360500_bib21","doi-asserted-by":"crossref","first-page":"10010","DOI":"10.1073\/pnas.1805343115","article-title":"Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2","volume":"115","author":"Sun","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023020312503360500_bib22","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/JB.181.16.4755-4760.1999","article-title":"Regulation of gene expression by glucose in Saccharomyces cerevisiae: a role for ADA2 and ADA3\/NGG1","volume":"181","author":"Wu","year":"1999","journal-title":"J Bacteriol"},{"key":"2023020312503360500_bib23","first-page":"4413","article-title":"Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene","volume":"45","author":"Church","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023020312503360500_bib24","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1091\/mbc.e08-11-1093","article-title":"Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA\/ADA complex in Candida albicans","volume":"20","author":"Sellam","year":"2009","journal-title":"Mol Biol Cell"},{"key":"2023020312503360500_bib25","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/EC.00163-09","article-title":"Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model","volume":"8","author":"Pukkila-Worley","year":"2009","journal-title":"Eukaryot Cell"},{"key":"2023020312503360500_bib26","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.2217\/fmb-2017-0084","article-title":"Histone acetyltransferase encoded by NGG1 is required for morphological conversion and virulence of Candida albicans","volume":"12","author":"Li","year":"2017","journal-title":"Future Microbiol"},{"key":"2023020312503360500_bib27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.fgb.2015.01.011","article-title":"Function and subcellular localization of Gcn5, a histone acetyltransferase in Candida albicans","volume":"81","author":"Chang","year":"2015","journal-title":"Fungal Genet Biol"},{"key":"2023020312503360500_bib28","doi-asserted-by":"crossref","first-page":"764711","DOI":"10.3389\/fcimb.2022.764711","article-title":"SAGA complex subunits in Candida albicans differentially regulate filamentation, invasiveness, and biofilm formation","volume":"12","author":"Rashid","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2023020312503360500_bib29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01924-17","article-title":"Deletion of ADA2 increases antifungal drug susceptibility and virulence in Candida glabrata","volume":"62","author":"Yu","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2023020312503360500_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nature02579","article-title":"Genome evolution in yeasts","volume":"430","author":"Dujon","year":"2004","journal-title":"Nature"},{"key":"2023020312503360500_bib31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.gene.2004.06.021","article-title":"The SAT1 flipper, an optimized tool for gene disruption in Candida albicans","volume":"341","author":"Reu\u00df","year":"2004","journal-title":"Gene"},{"key":"2023020312503360500_bib32","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/nar\/20.6.1425","article-title":"Improved method for high efficiency transformation of intact yeast cells","volume":"20","author":"Gietz","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"2023020312503360500_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"2023020312503360500_bib34","doi-asserted-by":"publisher","DOI":"10.3390\/jof4020068","article-title":"Conserved and divergent functions of the cAMP\/PKA signaling pathway in Candida albicans and Candida tropicalis","volume":"4","author":"Lin","year":"2018","journal-title":"J Fungi (Basel)"},{"key":"2023020312503360500_bib35","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts","author":"Institute","year":"2008"},{"key":"2023020312503360500_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394\u0394 C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2023020312503360500_bib37","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1128\/IAI.00817-06","article-title":"Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts","volume":"74","author":"MacCallum","year":"2006","journal-title":"Infect Immun"},{"key":"2023020312503360500_bib38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0092-8674(92)90100-Q","article-title":"Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains","volume":"70","author":"Berger","year":"1992","journal-title":"Cell"},{"key":"2023020312503360500_bib39","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/mmi.13528","article-title":"The SAGA complex in the rice pathogen Fusarium fujikuroi: structure and functional characterization","volume":"102","author":"R\u00f6sler","year":"2016","journal-title":"Mol Microbiol"},{"key":"2023020312503360500_bib40","doi-asserted-by":"crossref","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","article-title":"Mechanisms of antifungal drug resistance","volume":"5","author":"Cowen","year":"2014","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"2023020312503360500_bib41","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1038\/emboj.2011.181","article-title":"Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex","volume":"30","author":"Helmlinger","year":"2011","journal-title":"EMBO J"},{"key":"2023020312503360500_bib42","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1101\/gad.1979710","article-title":"Gcn5 regulates the dissociation of SWI\/SNF from chromatin by acetylation of Swi2\/Snf2","volume":"24","author":"Kim","year":"2010","journal-title":"Genes Dev"},{"key":"2023020312503360500_bib43","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1101\/gad.243584.114","article-title":"Swi\/Snf dynamics on stress-responsive genes is governed by competitive bromodomain interactions","volume":"28","author":"Dutta","year":"2014","journal-title":"Genes Dev"},{"key":"2023020312503360500_bib44","doi-asserted-by":"crossref","first-page":"194626","DOI":"10.1016\/j.bbagrm.2020.194626","article-title":"GCN5 acetyltransferase in cellular energetic and metabolic processes","volume":"1864","author":"Mutlu","year":"2021","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"2023020312503360500_bib45","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.1128\/JB.183.18.5385-5394.2001","article-title":"Biofilm formation by the fungal pathogen Candida albicans: development, architecture, and drug resistance","volume":"183","author":"Chandra","year":"2001","journal-title":"J Bacteriol"},{"key":"2023020312503360500_bib46","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1567-1364.2011.00785.x","article-title":"The Candida glabrata adhesin Epa1p causes adhesion, phagocytosis, and cytokine secretion by innate immune cells","volume":"12","author":"Kuhn","year":"2012","journal-title":"FEMS Yeast Res"},{"key":"2023020312503360500_bib47","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1128\/EC.00284-08","article-title":"The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins","volume":"7","author":"de Groot","year":"2008","journal-title":"Eukaryot Cell"},{"key":"2023020312503360500_bib48","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1073\/pnas.0611195104","article-title":"A family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of Candida glabrata","volume":"104","author":"Kaur","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023020312503360500_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrmicro2688","article-title":"The myriad roles of cyclic AMP in microbial pathogens: from signal to sword","volume":"10","author":"McDonough","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"2023020312503360500_bib50","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1574-6976.2011.00275.x","article-title":"Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae","volume":"36","author":"Br\u00fcckner","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"2023020312503360500_bib51","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.mib.2005.06.012","article-title":"A yeast by any other name: Candida glabrata and its interaction with the host","volume":"8","author":"Kaur","year":"2005","journal-title":"Curr Opin Microbiol"},{"key":"2023020312503360500_bib52","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1574-6976.2011.00278.x","article-title":"Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance","volume":"36","author":"Silva","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"2023020312503360500_bib53","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/ofid\/ofy358","article-title":"Twenty years of the SENTRY antifungal surveillance program: results for Candida species from 1997-2016","volume":"6","author":"Pfaller","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"2023020312503360500_bib54","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1101\/gad.1121003","article-title":"Virulence-related surface glycoproteins in the yeast pathogen Candida glabrata are encoded in subtelomeric clusters and subject to RAP1- and SIR-dependent transcriptional silencing","volume":"17","author":"De Las Penas","year":"2003","journal-title":"Genes Dev"},{"key":"2023020312503360500_bib55","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1365-2958.2004.04465.x","article-title":"Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata","volume":"55","author":"Castano","year":"2005","journal-title":"Mol Microbiol"},{"key":"2023020312503360500_bib56","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/mmi.12247","article-title":"Local silencing controls the oxidative stress response and the multidrug resistance in Candida glabrata","volume":"88","author":"Orta-Zavalza","year":"2013","journal-title":"Mol Microbiol"},{"key":"2023020312503360500_bib57","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00146-20","article-title":"Identification of Candida glabrata transcriptional regulators that govern stress resistance and virulence","author":"Filler","year":"2020","journal-title":"Infect Immun"},{"key":"2023020312503360500_bib58","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1534\/g3.118.200182","article-title":"A host-pathogen interaction screen identifies ada2 as a mediator of Candida glabrata defenses against reactive oxygen species","volume":"8","author":"Kounatidis","year":"2018","journal-title":"G3 (Bethesda)"},{"key":"2023020312503360500_bib59","doi-asserted-by":"crossref","first-page":"e0096322","DOI":"10.1128\/spectrum.00963-22","article-title":"Histone acetylation regulator Gcn5 mediates drug resistance and virulence of Candida glabrata","volume":"10","author":"Yu","year":"2022","journal-title":"Microbiol Spectr"},{"key":"2023020312503360500_bib60","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.tibs.2017.09.001","article-title":"Sharing the SAGA","volume":"42","author":"Helmlinger","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"2023020312503360500_bib61","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.molcel.2018.06.007","article-title":"SAGA is a general cofactor for RNA polymerase II transcription","volume":"70","author":"Baptista","year":"2018","journal-title":"Mol Cell"},{"key":"2023020312503360500_bib62","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0092-8674(04)00205-3","article-title":"Identification and distinct regulation of yeast TATA box-containing genes","volume":"116","author":"Basehoar","year":"2004","journal-title":"Cell"},{"key":"2023020312503360500_bib63","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1097-2765(04)00087-5","article-title":"A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae","volume":"13","author":"Huisinga","year":"2004","journal-title":"Mol Cell"},{"key":"2023020312503360500_bib64","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fmicb.2019.00602","article-title":"A potential antifungal effect of chitosan against Candida albicans is mediated via the inhibition of SAGA complex component expression and the subsequent alteration of cell surface integrity","volume":"10","author":"Shih","year":"2019","journal-title":"Front Microbiol"},{"key":"2023020312503360500_bib65","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1101\/gr.201244.115","article-title":"Chromatin dynamics during DNA replication","volume":"26","author":"Bar-Ziv","year":"2016","journal-title":"Genome Res"},{"key":"2023020312503360500_bib66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.molcel.2016.11.016","article-title":"Chromatin controls DNA replication origin selection, lagging-strand synthesis, and replication fork rates","volume":"65","author":"Kurat","year":"5 2017","journal-title":"Mol Cell"},{"key":"2023020312503360500_bib67","doi-asserted-by":"crossref","first-page":"e8964","DOI":"10.1371\/journal.pone.0008964","article-title":"GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae","volume":"5","author":"Espinosa","year":"2010","journal-title":"PLoS One"},{"key":"2023020312503360500_bib68","doi-asserted-by":"crossref","first-page":"194625","DOI":"10.1016\/j.bbagrm.2020.194625","article-title":"Cell cycle roles for GCN5 revealed through genetic suppression","volume":"1864","author":"Petty","year":"2021","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"2023020312503360500_bib69","doi-asserted-by":"crossref","first-page":"16040","DOI":"10.1074\/jbc.274.23.16040","article-title":"Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast","volume":"274","author":"Lee","year":"1999","journal-title":"J Biol Chem"},{"key":"2023020312503360500_bib70","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1074\/jbc.M115.696658","article-title":"Genome-wide screening of regulators of catalase expression: role of a transcription complex and histone and tRNA modification complexes on adaptation to stress","volume":"291","author":"Garcia","year":"2016","journal-title":"J Biol Chem"},{"key":"2023020312503360500_bib71","doi-asserted-by":"crossref","first-page":"9789","DOI":"10.1038\/s41598-020-66620-7","article-title":"Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata","volume":"10","author":"Ito","year":"2020","journal-title":"Sci Rep"},{"key":"2023020312503360500_bib72","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw005","article-title":"Role of Candida albicans secreted aspartyl protease Sap9 in interkingdom biofilm formation","volume":"74","author":"Dutton","year":"2016","journal-title":"Pathog Dis"},{"key":"2023020312503360500_bib73","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1126\/science.285.5427.578","article-title":"An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells","volume":"285","author":"Cormack","year":"1999","journal-title":"Science"},{"key":"2023020312503360500_bib74","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00065-15","article-title":"Upregulation of the adhesin gene EPA1 mediated by PDR1 in Candida glabrata leads to enhanced host colonization","volume":"1","author":"Vale-Silva","year":"2016","journal-title":"mSphere"},{"key":"2023020312503360500_bib75","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1365-2958.2004.04475.x","article-title":"The Yak1p kinase controls expression of adhesins and biofilm formation in Candida glabrata in a Sir4p-dependent pathway","volume":"55","author":"Iraqui","year":"2005","journal-title":"Mol Microbiol"},{"key":"2023020312503360500_bib76","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s42770-022-00703-7","article-title":"FLO8 deletion leads to decreased adhesion and virulence with downregulated expression of EPA1, EPA6, and EPA7 in Candida glabrata","volume":"53","author":"Zhao","year":"2022","journal-title":"Braz J Microbiol"},{"key":"2023020312503360500_bib77","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1567-1364.2010.00611.x","article-title":"Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata","volume":"10","author":"Miyazaki","year":"2010","journal-title":"FEMS Yeast Res"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myad004\/48946966\/myad004.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/61\/2\/myad004\/49085901\/myad004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/61\/2\/myad004\/49085901\/myad004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T12:51:34Z","timestamp":1675428694000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myad004\/7008851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,28]]},"references-count":77,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,3]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myad004","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2]]},"published":{"date-parts":[[2023,1,28]]},"article-number":"myad004"}}