{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:45:58Z","timestamp":1791582358141,"version":"4.3.4"},"reference-count":147,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cryptococcosis is a fungal disease of public health relevance that affects numerous animal species and humans, causing respiratory and neurological impairment. Hence, we conducted a systematic review that included publications from 1975 to 2021 and covered 132 articles that addressed reports of cryptococcosis in domestic and wild animals, its main clinical manifestations, pathological findings, etiology, diagnosis, and therapeutic protocols. We found that the highest number of reports of cryptococcosis is in domestic species, especially cats. Among the wild and\/or exotic animals, koalas and ferrets are the most affected, being important carriers of Cryptococcus spp. Pulmonary and neurological involvement is predominant in all species, although nonspecific clinical manifestations have been reported in various species, making clinical suspicion and diagnosis difficult. The countries with the most reports are Australia, the United States, Brazil, and Canada, with C. gattii VGI and VGII standing out. The therapies were based on azoles, amphotericin B, and 5-flucytosine, although there is no standard treatment protocol. Although, several diagnostic methods have been described, in a significant number of reports the diagnosis was made after a necropsy. Professionals are warned about diverse and nonspecific clinical manifestations in different animal species, which underlines the importance of cryptococcosis in the differential diagnosis in clinical practice. Furthermore, it is necessary to encourage the use of laboratory and molecular tools to improve the diagnosis of cryptococcosis. We also emphasize the urgent need for standardized therapeutic protocols to guide veterinary clinicians.<\/jats:p>","DOI":"10.1093\/mmy\/myad016","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T01:08:50Z","timestamp":1675472930000},"source":"Crossref","is-referenced-by-count":11,"title":["Cryptococcosis in domestic and wild animals: A review"],"prefix":"10.1093","volume":"61","author":[{"given":"Carolina dos Santos","family":"Bermann","sequence":"first","affiliation":[{"name":"Universidade Federal de Pelotas, Instituto de Biologia, Departamento de Microbiologia e Parasitologia, Laborat\u00f3rio de Micologia. Programa de P\u00f3s-Gradua\u00e7\u00e3o em Microbiologia e Parasitologia, Pelotas , RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Quintana","family":"Braga","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas, Instituto de Biologia, Departamento de Microbiologia e Parasitologia, Laborat\u00f3rio de Micologia. Programa de P\u00f3s-Gradua\u00e7\u00e3o em Microbiologia e Parasitologia, Pelotas , RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Baccarin","family":"Ianiski","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Centro de Ci\u00eancias da Sa\u00fade, Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas (PPGCF) , Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-9217","authenticated-orcid":false,"given":"S\u00f4nia de Avila","family":"Botton","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Centro de Ci\u00eancias da Sa\u00fade, Programa de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas (PPGCF) , Santa Maria, RS, Brazil"},{"name":"Universidade Federal de Santa Maria, Centro de Ci\u00eancias Rurais, Departamento de Medicina Veterin\u00e1ria Preventiva, Programa de P\u00f3s-gradua\u00e7\u00e3o em Medicina Veterin\u00e1ria (PPGMV) , Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-677X","authenticated-orcid":false,"given":"Daniela Isabel Brayer","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas, Instituto de Biologia, Departamento de Microbiologia e Parasitologia, Laborat\u00f3rio de Micologia. Programa de P\u00f3s-Gradua\u00e7\u00e3o em Microbiologia e Parasitologia, Pelotas , RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"2023021712233044200_","first-page":"675213","article-title":"Global molecular epidemiology of Cryptococcus neoformans and Cryptococcus gattii: an atlas of the molecular types","volume-title":"Scientifica (Cairo)","author":"Cogliati","year":"2013"},{"key":"2023021712233044200_","doi-asserted-by":"crossref","first-page":"e01087","DOI":"10.1128\/mBio.01087-13","article-title":"The Cryptococcus neoformans transcriptome at the site of human meningitis","volume":"5","author":"Chen","year":"2014","journal-title":"mBio"},{"key":"2023021712233044200_","first-page":"3797","article-title":"An\u00e1lise bibliogr\u00e1fica dos principais aspectos da criptococose","volume":"2","author":"Rego","year":"2019","journal-title":"Braz J 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