{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:31:48Z","timestamp":1791952308519,"version":"4.3.4"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Time-to-positivity (TTP) may assist in predicting the outcome of candidaemia. We analysed a candidaemia dataset collected prospectively in Australia over 1 year (2014\u20132015). TTP was defined as the period from blood culture sampling to the blood culture flagging positive. Of 415 candidaemia episodes, overall, 30-day mortality was 29% (120\/415); mortality with Candida albicans was 35% (59\/169), C. glabrata complex, 37% (43\/115), C. tropicalis, 43% (10\/23), Pichia kudriavzevii 25% (3\/12), and C. parapsilosis complex 7% (5\/71). Each day of increased TTP multiplied the odds ratio (OR) of survival at 30 days by a factor of 1.32 [95% confidence interval (CI) 1.06\u20131.69]. Shorter TTP was associated with increased mortality, with 1-day TTP associated with 30-day mortality 37% (41\/112) (95%CI: 28%\u201346%) and 5-day TTP 11% (2\/18) (95%CI: 2%\u201336%).<\/jats:p>","DOI":"10.1093\/mmy\/myad028","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T02:22:09Z","timestamp":1680747729000},"source":"Crossref","is-referenced-by-count":16,"title":["Time-to-positivity in bloodstream infection for <i>Candida<\/i> species as a prognostic marker for mortality"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-3488","authenticated-orcid":false,"given":"Caitlin","family":"Keighley","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital , Sydney, NSW 2145 , Australia"},{"name":"University of Sydney Institute for Infectious Diseases , 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