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This study determined the genetic relationship between isolates from Brazil and the United States through whole-genome sequencing and performed antifungal susceptibility testing to investigate drug resistance. Contrary to what is widely described, most isolates were susceptible to azoles. However, an atypical susceptibility profile was found in 50% of Candida pseudohaemulonii strains, including resistance to the three echinocandins. Isolates from both countries formed distinct clusters with wide genetic diversity. Isolates from three hospitals in Brazil were clonal and involved in candidemia cases, pointing to the importance of improving hospital infection control measures and molecular identification.<\/jats:p>","DOI":"10.1093\/mmy\/myad030","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T11:48:38Z","timestamp":1678967318000},"source":"Crossref","is-referenced-by-count":8,"title":["Whole-genome sequencing of\n                    <i>Candida haemulonii<\/i>\n                    species complex from Brazil and the United States: Genetic diversity and antifungal susceptibility"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0835-0948","authenticated-orcid":false,"given":"Dality Keffelen","family":"de Barros Rodrigues","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Universidade Federal do Mato Grosso do Sul , Mato Grosso do Sul , MS,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R","family":"Lockhart","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L","family":"Berkow","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Gade","sequence":"additional","affiliation":[{"name":"Mycotic Diseases Branch, Centers for Disease Control and Prevention , Atlanta, Georgia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Xavier","family":"Bonfietti","sequence":"additional","affiliation":[{"name":"N\u00facleo de Micologia do Instituto Adolfo Lutz, Secretaria de Sa\u00fade , S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Mazo F\u00e1vero Gimenes","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Micologia M\u00e9dica-LIM 53, Instituto de Medicina Tropical, Universidade de S\u00e3o Paulo , S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7374-8640","authenticated-orcid":false,"given":"Luciana","family":"Silva Ruiz","sequence":"additional","affiliation":[{"name":"N\u00facleo de Ci\u00eancias Biom\u00e9dicas, Instituto Adolfo Lutz , Regional Bauru, S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Bronze Macioni","sequence":"additional","affiliation":[{"name":"N\u00facleo de Micologia do Instituto Adolfo Lutz, Secretaria de Sa\u00fade , S\u00e3o Paulo , SP,","place":["Brazil"]},{"name":"Universidade Paulista , S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"de Souza Carvalho Melhem","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Doen\u00e7as Infecciosas e Parasit\u00e1rias, Universidade Federal do Mato Grosso do Sul , Mato Grosso do Sul , MS,","place":["Brazil"]},{"name":"N\u00facleo de Micologia do Instituto Adolfo Lutz, Secretaria de Sa\u00fade , S\u00e3o Paulo , SP,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"2026041420082463700_bib1","first-page":"78","article-title":"Torulopsis haemulonii nov. 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