{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T07:38:13Z","timestamp":1769845093613,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Scedosporium and Lomentospora species rank second among the filamentous fungi colonizing the airways of cystic fibrosis (CF) patients. These fungi could be responsible for allergic bronchopulmonary mycosis (ABPM) and bronchitis before lung transplantation and invasive infections after. However, their role in CF lung disease is debated. This study aimed to identify clinical or environmental factors associated with an airway colonization by Scedosporium\/Lomentospora species in patients with CF over a period of 7 years. A longitudinal cohort study was conducted from 2008 to 2014 in the CF reference centre in Lyon, France, to compare the characteristics of patients with Scedosporium\/Lomentospora colonized and non-colonized patients. During the study period, 283 patients completed the clinical and microbiological follow-up. The analysis revealed that a higher number and duration of hospitalizations, an increased number of courses of parenteral antibiotic therapy, a history of ABPA, and treatment by itraconazole were significantly associated with an airway colonization by Scedosporium\/Lomentospora species. The rate of decline of forced expiratory volume in the first second was not statistically different between colonized and non-colonized patients. This study provides evidence that patients colonized by Scedosporium\/Lomentospora species require more medical care than non-colonized patients. Additional care could be in part explained by the management of Scedosporium\/Lomentospora-related diseases such as ABPM or bronchitis. However, we did not demonstrate a faster rate of decline of respiratory function or body mass index in colonized patients, suggesting, as previously reported, that colonization of the airways by these fungi does not play a significant role in the progression of CF disease.<\/jats:p>","DOI":"10.1093\/mmy\/myad051","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T20:27:09Z","timestamp":1685737629000},"source":"Crossref","is-referenced-by-count":8,"title":["Outcome of patients with cystic fibrosis colonized by<i>Scedosporium<\/i>and<i>Lomentospora<\/i>species: A longitudinal cohort study"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-7518","authenticated-orcid":false,"given":"Perrine","family":"Parize","sequence":"first","affiliation":[{"name":"Service de maladies infectieuses et tropicales, H\u00f4pital Necker-Enfants malades, Groupe hospitalier AP-HP Centre, Universit\u00e9 Paris Cit\u00e9 , Paris , 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Claude Bernard Lyon 1, Inflammation & Immunit\u00e9 de l'Epith\u00e9lium Respiratoire \u2013 UR3738[CICLY] , Oullins , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Touzet","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon , Lyon , France"},{"name":"ICBMS CNRS 5246, Campus Lyon-Tech La Doua, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Lise","family":"Bienvenu","sequence":"additional","affiliation":[{"name":"Service de Pharmacie, Groupement Hospitalier Nord, Hospices Civils de Lyon , Lyon , France"},{"name":"ICBMS CNRS 5246, Campus Lyon-Tech La Doua, Universit\u00e9 de Lyon , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Wallon","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital de la Croix-Rousse, Service de Parasitologie et Mycologie m\u00e9dicale , Lyon , France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1, Waking team\u2014Centre de Recherche en Neurosciences de Lyon , Bron , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Reix","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, CRCM P\u00e9diatrique, H\u00f4pital Femme M\u00e8re Enfant , Bron , France"},{"name":"UMR5558 CNRS Equipe EMET, Universit\u00e9 Claude Bernard Lyon 1 , Lyon , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Philippe","family":"Bouchara","sequence":"additional","affiliation":[{"name":"Univ Angers, Universit\u00e9 de Bretagne Occidentale, CHU Angers, Groupe d'Etude des Interactions H\u00f4te-Pathog\u00e8ne [GEIHP, EA 3142], SFR ICAT 4208, Institut de Biologie en Sant\u00e9 , 49000 Angers , 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