{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:07:43Z","timestamp":1753877263228,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["2018-02186"],"award-info":[{"award-number":["2018-02186"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Patients with severe COVID-19 are at increased risk for invasive fungal infections, which are underestimated. Histoplasmosis reactivation in endemic areas should not be overlooked in this population. In a previous study, seroconversion to anti-histoplasmin antibodies by ELISA was detected in 6\/39 (15.4%) patients with severe COVID-19. In this work, samples were further investigated to detect seroconversion to antibodies against the Histoplasma capsulatum 100-kDa antigen (Hcp100) by ELISA. Seroconversion to anti-Hcp100 antibodies was detected in 7\/39 patients, of whom 6 also seroconverted anti-histoplasmin antibodies. These results reinforce previous findings that show histoplasmosis as an underdiagnosed fungal entity complicating COVID-19.<\/jats:p>","DOI":"10.1093\/mmy\/myad055","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T03:11:47Z","timestamp":1686193907000},"source":"Crossref","is-referenced-by-count":0,"title":["Evidence of anti-Hcp100 antibodies in COVID-19 critically ill patients with detectable anti-histoplasmin antibodies in a highly endemic area for histoplasmosis"],"prefix":"10.1093","volume":"61","author":[{"given":"Mar\u00eda A","family":"Toscanini","sequence":"first","affiliation":[{"name":"Instituto de Nanobiotecnolog\u00eda (NANOBIOTEC), Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires , CONICET, Buenos Aires , Argentina"},{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica(IMPaM), Universidad de Buenos Aires, CONICET, Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Barberis","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Infectolog\u00eda, Hospital Nacional Profesor Alejandro Posadas , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Unidad de Terapia Intensiva, Hospital Nacional Profesor Alejandro Posadas , Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Rodr\u00edguez\u00a0Laboccetta","sequence":"additional","affiliation":[{"name":"Instituto de Nanobiotecnolog\u00eda (NANOBIOTEC), Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires , CONICET, Buenos Aires , Argentina"},{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica(IMPaM), Universidad de Buenos Aires, CONICET, Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Videla\u00a0Garrido","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica(IMPaM), Universidad de Buenos Aires, CONICET, Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Fern\u00e1ndez\u00a0Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto de Nanobiotecnolog\u00eda (NANOBIOTEC), Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires , CONICET, Buenos Aires , Argentina"},{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica(IMPaM), Universidad de Buenos Aires, CONICET, Buenos Aires , Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys B","family":"Posse","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda. 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