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We aimed to describe the clinical characteristics of adults with N. glabrata candidaemia at 20 sentinel hospitals (accounting for 20% (172\/917) of cases) and the antifungal susceptibility of the corresponding isolates. A higher proportion of patients with N. glabrata candidaemia were older (median age: 55 years [interquartile range (IQR): 41\u201365 years] vs. 49 years [IQR: 35-63 years]; p\u00a0=\u00a00.04), female (87\/164, 53% vs. 283\/671, 42%; p\u00a0=\u00a00.01), admitted to a public-sector hospital (152\/172, 88% vs. 470\/745, 63%; p\u00a0&amp;lt;\u00a00.001), treated with fluconazole only (most with suboptimal doses) (51\/95, 54% vs. 139\/361, 39%; p\u00a0&amp;lt;\u00a00.001), and had surgery (47\/172, 27% vs. 123\/745, 17%; p\u00a0=\u00a00.001) and a shorter hospital stay (median 7 days [IQR: 2-20 days] vs. 13 days [IQR: 4-27 days]; p\u00a0&amp;lt;\u00a00.001) compared to patients with other causes of candidaemia. Eight N. glabrata isolates (6%, 8\/131) had minimum inhibitory concentrations in the intermediate or resistant range for\u00a0\u2265\u00a01 echinocandin and a R1377K amino acid substitution encoded by the hotspot 2 region of the FKS2 gene. Only 11 isolates (8%, 11\/131) were resistant to fluconazole. Patients with confirmed N. glabrata candidaemia are recommended to be treated with an echinocandin (or polyene), thus further guideline training is required.<\/jats:p>","DOI":"10.1093\/mmy\/myad057","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:49:39Z","timestamp":1687222179000},"source":"Crossref","is-referenced-by-count":8,"title":["Epidemiology and susceptibility of <i>Nakaseomyces<\/i> (formerly <i>Candida<\/i>) <i>glabrata<\/i> bloodstream isolates from hospitalised adults in South Africa"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4445-1482","authenticated-orcid":false,"given":"Serisha D","family":"Naicker","sequence":"first","affiliation":[{"name":"Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, a Division of the National Health Laboratory Service , Johannesburg , South 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