{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:57:35Z","timestamp":1792195055254,"version":"4.4.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordination for the Improvement of Higher Education Personnel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007380","name":"FIPE","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Intestinal fungi play an important role in the health-disease process. We observed that in liver diseases, fungal infections lead to high mortality. In this review, we were able to gather and evaluate the available scientific evidence on intestinal mycobiota and liver diseases. We searched PubMed and Embase, using a combination of several entry terms. Only studies in adults\u00a0\u2265\u00a018 years old with liver disease and published after 2010 were included. We observed that individuals with liver disease have an altered intestinal mycobioma, which accompanies the progression of these diseases. In cirrhotic patients, there are a high number of Candida sp. strains, especially Candida albicans. In early chronic liver disease, there is an increase in alpha diversity at the expense of Candida sp. and conversely, in advanced liver disease, there is a negative correlation between alpha diversity and model for end-stage liver disease score. On the other hand, patients with non-alcoholic fatty liver disease demonstrate greater diversity compared to controls. Our study concluded that the evidence on the subject is sparse, with few studies and a lack of standardization of outcome measures and reporting, and it was not possible to perform a meta-analysis capable of synthesizing relevant parameters of the human mycobiotic profile. However, certain fungal genera such as Candida play an important role in the context of liver disease and that adults with liver disease have a distinct gut mycobiotic profile from healthy controls.<\/jats:p>","DOI":"10.1093\/mmy\/myad071","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T01:40:06Z","timestamp":1689730806000},"source":"Crossref","is-referenced-by-count":3,"title":["Gut mycobiota changes in liver diseases: A systematic review"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-7588","authenticated-orcid":false,"given":"C\u00e1ssio Marques","family":"Perlin","sequence":"first","affiliation":[{"name":"Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul , Porto Alegre, 90035-002 , Brazil"},{"name":"Experimental Laboratory of Hepatology and Gastroenterology, Experimental Research Center, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, 90035-903 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisse","family":"Longo","sequence":"additional","affiliation":[{"name":"Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul , Porto Alegre, 90035-002 , Brazil"},{"name":"Experimental Laboratory of Hepatology and Gastroenterology, Experimental Research Center, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, 90035-903 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina Bel\u00e9n","family":"Keingeski","sequence":"additional","affiliation":[{"name":"Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul , Porto Alegre, 90035-002 , Brazil"},{"name":"Experimental Laboratory of Hepatology and Gastroenterology, Experimental Research Center, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, 90035-903 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael V","family":"Picon","sequence":"additional","affiliation":[{"name":"Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul , Porto Alegre, 90035-002 , Brazil"},{"name":"School of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul; Division of Gastroenterology, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, 90035-903 , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio Reis","family":"\u00c1lvares-da-Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul , Porto Alegre, 90035-002 , Brazil"},{"name":"Experimental Laboratory of Hepatology and Gastroenterology, Experimental Research Center, Hospital de Cl\u00ednicas de Porto Alegre , Porto Alegre, 90035-903 , Brazil"},{"name":"School of Medicine, Department of Internal Medicine, Universidade Federal do Rio Grande do Sul; Division 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