{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:42:10Z","timestamp":1789580530358,"version":"build-2803163510"},"reference-count":178,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100017128","name":"Natural Science Foundation for Distinguished Young Scholars of Anhui Province","doi-asserted-by":"publisher","award":["2008085J40"],"award-info":[{"award-number":["2008085J40"]}],"id":[{"id":"10.13039\/100017128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Oropharyngeal candidiasis (OPC), commonly known as \u2018thrush\u2019, is an oral infection that usually dismantles oral mucosal integrity and malfunctions local innate and adaptive immunities in compromised individuals. The major pathogen responsible for the occurrence and progression of OPC is the dimorphic opportunistic commensal Candida albicans. However, the incidence induced by non-albicans Candida species including C. glabrata, C. tropicalis, C. dubliniensis, C. parapsilosis, and C. krusei are increasing in company with several oral bacteria, such as Streptococcus mutans, S. gordonii, S. epidermidis, and S. aureus. In this review, the microbiological and infection features of C. albicans and its co-contributors in the pathogenesis of OPC are outlined. Since the invasion and concomitant immune response lie firstly on the recognition of oral pathogens through diverse cellular surface receptors, we subsequently emphasize the roles of epidermal growth factor receptor, ephrin-type receptor 2, human epidermal growth factor receptor 2, and aryl hydrocarbon receptor located on oral epithelial cells to delineate the underlying mechanism by which host immune recognition to oral pathogens is mediated. Based on these observations, the therapeutic approaches to OPC comprising conventional and non-conventional antifungal agents, fungal vaccines, cytokine and antibody therapies, and antimicrobial peptide therapy are finally overviewed. In the face of newly emerging life-threatening microbes (C. auris and SARS-CoV-2), risks (biofilm formation and interconnected translocation among diverse organs), and complicated clinical settings (HIV and oropharyngeal cancer), the research on OPC is still a challenging task.<\/jats:p>","DOI":"10.1093\/mmy\/myad077","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T04:58:29Z","timestamp":1691038709000},"source":"Crossref","is-referenced-by-count":4,"title":["Perspective on receptor-associated immune response to <i>Candida albicans<\/i> single and mixed infections: Implications for therapeutics in oropharyngeal candidiasis"],"prefix":"10.1093","volume":"61","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Anti-infection and Immunity, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine , Zhijing Building, 350 Longzihu Road, Xinzhan District, Hefei 230012 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Cheng","sequence":"additional","affiliation":[{"name":"Laboratory of Anti-infection and Immunity, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine , Zhijing Building, 350 Longzihu Road, Xinzhan District, Hefei 230012 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-2969","authenticated-orcid":false,"given":"Jing","family":"Shao","sequence":"additional","affiliation":[{"name":"Laboratory of Anti-infection and Immunity, College of Integrated Chinese and Western Medicine (College of Life Science), Anhui University of Chinese Medicine , Zhijing Building, 350 Longzihu Road, Xinzhan District, Hefei 230012 , P. R. China"},{"name":"Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine , Zhijing Building, 350 Longzihu Road, Xinzhan District, Hefei 230012 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"2023080817252002800_bib1","doi-asserted-by":"crossref","first-page":"eaam8834","DOI":"10.1126\/sciimmunol.aam8834","article-title":"Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin","volume":"2","author":"Verma","year":"2017","journal-title":"Sci Immunol"},{"key":"2023080817252002800_bib2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3389\/fmicb.2018.00980","article-title":"Oropharyngeal candidosis in HIV-infected patients-an update","volume":"9","author":"Patil","year":"2018","journal-title":"Front Microbiol"},{"key":"2023080817252002800_bib3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/jop.13266","article-title":"Revisiting oral thrush in South-East Asian patients: A review of published studies 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