{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:34:43Z","timestamp":1793705683572,"version":"4.5.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2018-02186"],"award-info":[{"award-number":["PICT 2018-02186"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In cystic fibrosis (CF) patients, fungal colonization of the respiratory tract is frequently found. Aspergillus fumigatus, Scedosporium genus, and Exophiala dermatitidis are the most commonly isolated moulds from the respiratory tract secretions of CF patients. The aim of this 5-year surveillance study was to identify trends in species distribution and susceptibility patterns of 212 mould strains identified as Aspergillus spp., Scedosporium spp., and Exophiala spp., isolated from sputum of 63 CF patients who received long-term therapy with itraconazole (ITR) and\/or voriconazole (VRC). The Aspergillus isolates were identified as members of the sections Fumigati (n\u00a0=\u00a0130), Flavi (n\u00a0=\u00a022), Terrei (n\u00a0=\u00a020), Nigri (n\u00a0=\u00a08), Nidulantes (n\u00a0=\u00a01), and Usti (n\u00a0=\u00a01). Among the 16 species of the genus Scedosporium, 9 were S. apiospermum, 3 S. aurantiacum, and 4 S. boydii. Among the 14 Exophiala species, all were molecularly identified as E. dermatitidis. Overall, 94% (15\/16) of Scedosporium spp., 50% (7\/14) of E. dermatitidis, and 7.7% (14\/182) of Aspergillus spp. strains showed high MIC values (\u22658\u00a0\u00b5g\/ml) for at least one antifungal. Particularly, 8.9% (19\/212) of isolates showed high MIC values for amphotericin B, 11.7% (25\/212) for ITR, 4.2% (9\/212) for VRC, and 3.3% (7\/212) for posaconazole. In some cases, such as some A. fumigatus and E. dermatitidis isolates recovered from the same patient, susceptibility to antifungal azoles decreased over time. We show that the use of azoles for a long time in CF patients causes the selection\/isolation of mould strains with higher MIC values.<\/jats:p>","DOI":"10.1093\/mmy\/myad089","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T20:45:14Z","timestamp":1692132314000},"source":"Crossref","is-referenced-by-count":4,"title":["Antifungal susceptibility patterns for <i>Aspergillus, Scedosporium<\/i>, and <i>Exophiala<\/i> isolates recovered from cystic fibrosis patients against amphotericin B, and three triazoles and their impact after long-term therapies"],"prefix":"10.1093","volume":"61","author":[{"given":"Tom\u00e1s","family":"Brito\u00a0Devoto","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo en Micolog\u00eda, Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica, Universidad de Buenos Aires-CONICET , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hermida-Alva","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo en Micolog\u00eda, Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica, Universidad de Buenos Aires-CONICET , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys","family":"Posse","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda, Hospital Nacional Profesor Alejandro Posadas , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L","family":"Finquelievich","sequence":"additional","affiliation":[{"name":"Centro de Micolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3927-4650","authenticated-orcid":false,"given":"Guillermo","family":"Garc\u00eda-Effr\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular, C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral , Santa Fe , Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET) , Santa Fe , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4467-996X","authenticated-orcid":false,"given":"Mar\u00eda L","family":"Cuestas","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo en Micolog\u00eda, Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica, Universidad de Buenos 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