{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:47:11Z","timestamp":1790725631246,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K16000"],"award-info":[{"award-number":["JP20K16000"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K07022"],"award-info":[{"award-number":["JP20K07022"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23fk0108679h0401"],"award-info":[{"award-number":["JP23fk0108679h0401"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida auris is an emerging fungal pathogen that is feared to spread of infection because of its propensity for multidrug resistance and high mortality rate. This pathogenic yeast is classified into four major clades by phylogenetic analyses, which are referred to the South Asia clade (clade I), East Asia clade (clade II), South Africa clade (clade III), and South America clade (clade IV), based on the location of the initial isolate. In this study, we evaluated the virulence of C. auris strains belonging to four major clades and the therapeutic effects of micafungin in a silkworm infection model. The highest mortality rate at 21\u00a0h after C. auris inoculation was observed for strains from clade IV (80% or more). In contrast, it was 20% or less in those from other clades. Antifungal susceptibility tests indicated resistance to fluconazole and sensitivity to echinocandins in the blood-derived strains. Micafungin prolonged the survival of blood-derived C. auris infected silkworms. These results suggest that the silkworm infection model is useful for evaluating the virulence of C. auris and determining its therapeutic effects.<\/jats:p>","DOI":"10.1093\/mmy\/myad108","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T01:37:15Z","timestamp":1698543435000},"source":"Crossref","is-referenced-by-count":17,"title":["Comparing the virulence of four major clades of <i>Candida auris<\/i> strains using a silkworm infection model: Clade IV isolates had higher virulence than the other clades"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-7878","authenticated-orcid":false,"given":"Sanae","family":"Kurakado","sequence":"first","affiliation":[{"name":"Department of Microbiology, Meiji Pharmaceutical University , 2-522-1, Noshio, Kiyose, Tokyo 204-8588 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-2304","authenticated-orcid":false,"given":"Yasuhiko","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Meiji Pharmaceutical University , 2-522-1, Noshio, Kiyose, Tokyo 204-8588 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2127-5017","authenticated-orcid":false,"given":"Takashi","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Meiji Pharmaceutical University , 2-522-1, Noshio, Kiyose, Tokyo 204-8588 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"2023111619145417100_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","article-title":"Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital","volume":"53","author":"Satoh","year":"2009","journal-title":"Microbiol Immunol"},{"key":"2023111619145417100_bib2","doi-asserted-by":"crossref","first-page":"e1008921","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: Epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"Du","year":"2020","journal-title":"PLoS Pathog"},{"key":"2023111619145417100_bib3","doi-asserted-by":"crossref","first-page":"myad072","DOI":"10.1093\/mmy\/myad072","article-title":"Yeasts from blood cultures in the wake of the COVID-19 pandemic in a tertiary care hospital: Shift in species epidemiology, steady low antifungal resistance and full in vitro ibrexafungerp activity","volume":"61","author":"D\u00edaz-Garc\u00eda","year":"2023","journal-title":"Med Mycol"},{"key":"2023111619145417100_bib4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.3201\/eid2907.221888","article-title":"Nationwide outbreak of Candida auris infections driven by COVID-19 hospitalizations, Israel, 2021\u20132022","volume":"29","author":"Biran","year":"2023","journal-title":"Emerg Infect. 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