{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:06:45Z","timestamp":1793801205007,"version":"4.6.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005668","name":"FAPDF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Germline-encoded pattern recognition receptors, particularly C-type lectin receptors (CLRs), are essential for phagocytes to sense invading fungal cells. Among CLRs, Dectin-2 (encoded by Clec4n) plays a critical role in the antifungal immune response as it recognizes high-mannose polysaccharides on the fungal cell wall, triggering phagocyte functional activities and ultimately determining adaptive responses. Here, we assessed the role of Dectin-2 on the course of primary Paracoccidioides brasiliensis systemic infection in mice with Dectin-2-targeted deletion. Paracoccidioides brasiliensis constitutes the principal etiologic agent of paracoccidioidomycosis, the most prominent invasive mycosis in Latin American countries. The deficiency of Dectin-2 resulted in shortened survival rates, high lung fungal burden, and increased lung pathology in mice infected with P. brasiliensis. Consistently, dendritic cells (DCs) from mice lacking Dectin-2 infected ex vivo with P. brasiliensis showed impaired secretion of several proinflammatory and regulatory cytokines, including TNF-\u03b1, IL-1\u03b2, IL-6, and IL-10. Additionally, when cocultured with splenic lymphocytes, DCs were less efficient in promoting a type 1 cytokine pattern secretion (i.e., IFN-\u03b3). In macrophages, Dectin-2-mediated signaling was required to ensure phagocytosis and fungicidal activity associated with nitric oxide production. Overall, Dectin-2-mediated signaling is critical to promote host protection against P. brasiliensis infection, and its exploitation might lead to the development of new vaccines and immunotherapeutic approaches.<\/jats:p>","DOI":"10.1093\/mmy\/myad117","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:48:41Z","timestamp":1699948121000},"source":"Crossref","is-referenced-by-count":6,"title":["Dectin-2 is critical for phagocyte function and resistance to <i>Paracoccidioides brasiliensis<\/i> in mice"],"prefix":"10.1093","volume":"61","author":[{"given":"Mariana de Resende Damas","family":"Cardoso-Miguel","sequence":"first","affiliation":[{"name":"Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"},{"name":"Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique","family":"B\u00fcrgel","sequence":"additional","affiliation":[{"name":"Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"},{"name":"Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffael J\u00fanio Ara\u00fajo","family":"de\u00a0Castro","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Luna","family":"Marina","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan Alberto","family":"de\u00a0Oliveira","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"},{"name":"Department of Cell Biology, Laboratory of Molecular Biology of Pathogenic Fungi, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"},{"name":"Laboratory of Microorganism, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildinete","family":"Silva-Pereira","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Laboratory of Molecular Biology of Pathogenic Fungi, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anam\u00e9lia Lorenzetti","family":"Bocca","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-3380","authenticated-orcid":false,"given":"Aldo Henrique","family":"Tavares","sequence":"additional","affiliation":[{"name":"Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"},{"name":"Laboratory of Microorganism, Faculty of Ceil\u00e2ndia, University of Bras\u00edlia , Bras\u00edlia, DF , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"2023112322051986300_bib1","doi-asserted-by":"crossref","first-page":"e0011136","DOI":"10.1371\/journal.pntd.0011136","article-title":"Recognition of fungal priority pathogens: what next?","volume":"17","author":"Rodrigues","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"key":"2023112322051986300_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jof3010001","article-title":"New trends in paracoccidioidomycosis epidemiology","volume":"3","author":"Martinez","year":"2017","journal-title":"J Fungi"},{"key":"2023112322051986300_bib3","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/jof8101098","article-title":"Paracoccidioidomycosis: what we know and what is new in epidemiology, 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