{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:25:29Z","timestamp":1778185529926,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["82071265"],"award-info":[{"award-number":["82071265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although non-human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM) is a severe disease, there are still some non-HIV CM patients with a low risk of therapeutic failure. Recognizing clinical characteristics of low-risk non-HIV-associated CM may enable clinicians to treat non-HIV-associated CM more reasonably. According to the definition of low-risk non-HIV-associated CM in the 2010 Infectious Diseases Society of America guideline, a total of 220 non-HIV CM patients were divided into two groups (Group 1: 35 low-risk patients and Group 2: 185 non-low-risk patients). Clinical characteristics, treatment, and outcome were compared between the two groups. Compared with non-low-risk patients, low-risk patients had a lower rate of headache (82.9% vs. 95.7%, P\u00a0=\u00a0.012), cerebrospinal fluid (CSF) opening pressure (OP) at baseline (CSF OP\u00a0&amp;lt;\u00a0250-mm H2O, 60.0% vs. 32.4%, P\u00a0=\u00a0.001), and baseline CSF cryptococcal count (median, 0 vs. 2376, P\u00a0&amp;lt;\u00a0.001), higher baseline CSF white blood cell (median, 130 vs. 90, P\u00a0=\u00a0.029) and CSF protein (median, 0.87 vs. 0.73, P\u00a0=\u00a0.011). Multivariate analysis showed that baseline CSF OP\u00a0&amp;lt;250-mm H2O (OR: 2.545, 95% CI 1.168, 5.545, P\u00a0=\u00a0.019) was independently associated with low-risk for non-HIV-associated CM. The lengths of AMB-d-based induction therapy of low-risk patients (median, 20 days) were shorter (P\u00a0&amp;lt;\u00a0.001) than that of non-low-risk patients (median, 38 days). The successful outcome rate of low-risk patients was higher than non-low-risk patients (97.1% vs. 54.6%, P\u00a0&amp;lt;\u00a0.001). We demonstrated that non-HIV-associated CM patients with baseline CSF OP\u00a0&amp;lt; 250-mm H2O were prone to the low-risk status.<\/jats:p>","DOI":"10.1093\/mmy\/myad122","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T05:40:26Z","timestamp":1701322826000},"source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics, treatment, and outcome of low-risk non-HIV-associated cryptococcal meningitis: A retrospective cohort study"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-9720","authenticated-orcid":false,"given":"Junyu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510630 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiqi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510630 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shenzhen University General Hospital , Shenzhen, Guangdong 518055 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510630 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou, Guangdong 510630 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Third 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