{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:46:40Z","timestamp":1769838400868,"version":"3.49.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["22K08442"],"award-info":[{"award-number":["22K08442"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Milbemycin oximes are macrocyclic lactones that have a broad spectrum of activity against nematode infection in animals. They are known to block drug efflux, which increases the susceptibility of fungi to azoles. We investigated the effects of milbemycin on the azole susceptibility of fungi (Aspergillus fumigatus, Candida albicans, C. auris, Cryptococcus neoformans, and Trichophyton rubrum). To screen for changes in azole susceptibility, fungal growth was tested on a culture medium containing 1 \u03bcg\/ml milbemycin. The results showed that milbemycin increased the azole susceptibility of azole-resistant strains of C. albicans, C. auris, C. neoformans, and T. rubrum. Thus, milbemycin might be useful against antifungal drug-resistant strains.<\/jats:p>","DOI":"10.1093\/mmy\/myae003","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T17:38:38Z","timestamp":1706549918000},"source":"Crossref","is-referenced-by-count":4,"title":["Is milbemycin a game changer against antifungal drug-resistant mycoses?"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-629X","authenticated-orcid":false,"given":"Rui","family":"Kano","sequence":"first","affiliation":[{"name":"Teikyo University Institute of Medical Mycology (TIMM) , 359 Otsuka, Hachioji, Tokyo 192-0395 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Yamada","sequence":"additional","affiliation":[{"name":"Teikyo University Institute of Medical Mycology (TIMM) , 359 Otsuka, Hachioji, Tokyo 192-0395 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tamura","sequence":"additional","affiliation":[{"name":"General Medical Education and Research Center, Teikyo University , 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Makimura","sequence":"additional","affiliation":[{"name":"Teikyo University Institute of Medical Mycology (TIMM) , 359 Otsuka, Hachioji, Tokyo 192-0395 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"2024022222174722000_bib1","first-page":"e01719","article-title":"The future of antifungal drug therapy: novel compounds and targets","volume":"65","author":"Mota\u00a0Fernandes","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2024022222174722000_bib2","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.1038\/s41467-022-32249-5","article-title":"The importance of antimicrobial resistance in medical mycology","volume":"13","author":"Gow","year":"2022","journal-title":"Nat Commun"},{"key":"2024022222174722000_bib3","first-page":"1","article-title":"Emerging fungal infections: from the fields to the clinic, resistant Aspergillus fumigatus and dermatophyte species: a one health perspective on an urgent public health problem","volume":"27","author":"Langfeldt","year":"2022","journal-title":"Curr Clin Microbiol Rep"},{"key":"2024022222174722000_bib4","article-title":"WHO fungal priority pathogens list to guide research, development and public health action","author":"WHO"},{"key":"2024022222174722000_bib5","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1128\/AAC.02040-12","article-title":"Milbemycins: more than efflux inhibitors for fungal pathogens","volume":"57","author":"Silva","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"2024022222174722000_bib6","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/1567-1364.12164","article-title":"Milbemycin A4 oxime as a probe of azole transport in Candida glabrata","volume":"14","author":"Walker","year":"2014","journal-title":"FEMS Yeast Res"},{"key":"2024022222174722000_bib7","doi-asserted-by":"crossref","first-page":"e00863","DOI":"10.1128\/AAC.00863-19","article-title":"Trichophyton rubrum azole resistance mediated by a new ABC transporter, TruMDR3","volume":"63","author":"Monod","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"2024022222174722000_bib8","first-page":"e0239321","article-title":"Clinical isolate of a multi-antifungal-resistant Trichophyton rubrum","volume-title":"Antimicrob Agents Chemother","author":"Kano","year":"2022"},{"key":"2024022222174722000_bib9","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts","author":"Clinical Laboratory Standards Institute","year":"2017","edition":"4th edn"},{"key":"2024022222174722000_bib10","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi","author":"Clinical Laboratory Standards Institute","year":"2017","edition":"3rd edn"},{"key":"2024022222174722000_bib11","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1128\/AAC.47.5.1719-1726.2003","article-title":"Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole","volume":"47","author":"Nascimento","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"2024022222174722000_bib12","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2174\/138920112800399059","article-title":"Acute human toxicity of macrocyclic lactones","volume":"13","author":"Yang","year":"2012","journal-title":"Curr Pharm Biotechnol"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myae003\/56447478\/myae003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/62\/2\/myae003\/56743898\/myae003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/62\/2\/myae003\/56743898\/myae003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T22:20:34Z","timestamp":1708640434000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myae003\/7591307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,27]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,27]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myae003","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2]]},"published":{"date-parts":[[2024,1,27]]},"article-number":"myae003"}}