{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T19:50:52Z","timestamp":1776887452332,"version":"3.51.2"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031252","name":"Carigest SA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In Ghana, most laboratory diagnoses of severe mycoses are based on histopathology findings due to inadequate availability of serology, culture, and molecular tests. The aim of this study was to evaluate the spectrum of mycoses diagnosed in Ghana. We retrospectively reviewed reports from 2012 to 2021 from three major pathology laboratories in Ghana to identify reports indicating the presence of fungal elements and diagnosis of a mycosis, then extracted demographic, clinical history, site of infection, stain(s), used and diagnosed mycosis details. Over the 10-year period, 107 cases were found. No apparent increasing and decreasing trend in the number of cases per year or in a period was observed. The age range of affected patients was from 4 to 86 years. Special stains for fungi were only used in 22 of 107 (20.6%) of cases. The most frequently affected site was the sino-nasal area (34%). Mycosis type was determined for 58 (54.2%) cases, comprising aspergillosis (21), candidiasis (14), dermatophytosis (6), mucormycosis (3), two cases each of chromoblastomycosis, histoplasmosis, eumycetoma, entomophthoromycosis, sporotrichosis, and Malassezia infection and a single case each of cryptococcosis and deep onychomycosis. Of the 53 (49.5%) cases with presumptive diagnosis data, only seven (13.2%) had a pre-biopsy suspicion of mycosis. There is a wide spectrum of mycoses in Ghana, including endemic mycoses not previously reported. Improving the use of special fungal stains could increase yield and mycoses identification. Laboratory diagnostic capacity needs enhancement to complement histopathology investigations with serology, culture, and molecular methods.<\/jats:p>","DOI":"10.1093\/mmy\/myae015","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T02:54:20Z","timestamp":1708570460000},"source":"Crossref","is-referenced-by-count":4,"title":["A diverse spectrum of mycoses histologically diagnosed in Ghana: Insights from a 10-year retrospective study"],"prefix":"10.1093","volume":"62","author":[{"given":"Bright","family":"Ocansey","sequence":"first","affiliation":[{"name":"Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, M13 9NT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Erskine","sequence":"additional","affiliation":[{"name":"Department of Pathology, Korle-Bu Teaching Hospital and University of Ghana Medical School , Korle-Bu, GA-221-1570 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard","family":"Okine","sequence":"additional","affiliation":[{"name":"Cellular Pathology Division, Ghana Standard Authority , Accra, GA-288-5605 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Potakey","sequence":"additional","affiliation":[{"name":"Department of Pathology, Korle-Bu Teaching Hospital and University of Ghana Medical School , Korle-Bu, GA-221-1570 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prince","family":"Pappoe-Ashong","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Ghana Medical School , Korle-Bu, GA-270-4330 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Sraku","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Ghana Medical School , Korle-Bu, GA-270-4330 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Quayson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Korle-Bu Teaching Hospital and University of Ghana Medical School , Korle-Bu, GA-221-1570 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Japheth","family":"Opintan","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, University of Ghana Medical School , Korle-Bu, GA-270-4330 , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, M13 9NT , UK"},{"name":"National Aspergillosis Centre, Manchester University NHS Foundation Trust , Manchester, M23 9LT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Denning","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester, M13 9NT , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"2024030715551219800_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3390\/tropicalmed4040122","article-title":"The diagnosis of fungal neglected tropical diseases (Fungal NTDs) and the role of investigation and laboratory tests: an expert consensus report","volume":"4","author":"Hay","year":"2019","journal-title":"Trop Med Infect Dis"},{"key":"2024030715551219800_bib2","article-title":"WHO fungal priority pathogens list to guide research, development and public health 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