{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:45:45Z","timestamp":1775612745738,"version":"3.50.1"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although Candida species are the most common cause of fungemia, non-Candida rare yeasts (NCY) have been increasingly reported worldwide. Although the importance of these yeast infections is recognized, current epidemiological information about these pathogens is limited, and they have variable antifungal susceptibility profiles. In this study, we aimed to evaluate the clinical characteristics for fungemia caused by NCY by comparing with candidemia. The episodes of NCY fungemia between January 2011 and August 2023 were retrospectively evaluated in terms of clinical characteristics, predisposing factor, and outcome. In addition, a candidemia group, including patients in the same period was conducted for comparison. Antifungal susceptibility tests were performed according to the reference method. A total of 85 patients with fungemia episodes were included: 25 with NCY fungemia and 60 with candidemia. Fluconazole had high minimal inhibitory concentration (MIC) values against almost all NCY isolates. The MIC values for voriconazole, posaconazole, and amphotericin B were \u2264 2\u2009\u00b5g\/ml, and for caspofungin and anidulafungin were \u2265 1\u2009\u00b5g\/ml against most of isolates. Hematological malignancies, immunosuppressive therapy, neutropenia and prolonged neutropenia, polymicrobial bacteremia\/fungemia, preexposure to antifungal drugs, and breakthrough fungemia were associated with NCY fungemia, whereas intensive care unit admission, diabetes mellitus, urinary catheters, and total parenteral nutrition were associated with candidemia. In conclusion, the majority of fungemia due to NCY species was the problem, particularly in hematology units and patients with hematological malignancy. Preexposure to antifungal drugs likely causes a change in the epidemiology of fungemia in favor of non-albicans Candida and\/or NCY.<\/jats:p>","DOI":"10.1093\/mmy\/myae037","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T03:01:05Z","timestamp":1713322865000},"source":"Crossref","is-referenced-by-count":3,"title":["Comparison of fungemia caused by <i>Candida<\/i> and non-<i>Candida<\/i> rare yeasts: a retrospective study from a tertiary care hospital"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-7644","authenticated-orcid":false,"given":"Yasemin","family":"Oz","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical Faculty, Eskisehir Osmangazi University , 26040, Eskisehir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical Faculty, Eskisehir Osmangazi University , 26040, Eskisehir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Bulduk","sequence":"additional","affiliation":[{"name":"Department of Hematology, Medical Faculty, Eskisehir Osmangazi University , 26040, Eskisehir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Basayigit","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical Faculty, Eskisehir Osmangazi University , 26040, Eskisehir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Gunduz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Medical Faculty, Eskisehir Osmangazi University , 26040, Eskisehir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Metintas","sequence":"additional","affiliation":[{"name":"Department of Public Health, Medical Faculty, Eskisehir Osmangazi University , 26040, Eskisehir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"6","key":"2024050310313196600_bib1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1080\/14737159.2023.2215929","article-title":"Updates on the profile of GenMark\u2019s ePlex blood culture identification fungal pathogen panel","volume":"23","author":"Mizusawa","year":"2023","journal-title":"Expert Rev Mol Diagn"},{"issue":"12","key":"2024050310313196600_bib2","doi-asserted-by":"crossref","first-page":"e375","DOI":"10.1016\/S1473-3099(21)00203-6","article-title":"Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM","volume":"21","author":"Chen","year":"2021","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"2024050310313196600_bib3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1128\/JCM.03268-12","article-title":"Comparison between the Biflex III-Biotyper and the Axima-SARAMIS systems for yeast identification by matrix-assisted laser desorption ionization-time of flight mass spectrometry","volume":"51","author":"Lohmann","year":"2013","journal-title":"J Clin Microbiol"},{"key":"2024050310313196600_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/1469-0691.12360","article-title":"ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections","volume":"20","author":"Arendrup","year":"2014","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"2024050310313196600_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/myc.12852","article-title":"The epidemiology of non-Candida yeast isolated from blood: the Asia Surveillance Study","volume":"62","author":"Lin","year":"2019","journal-title":"Mycoses"},{"issue":"2","key":"2024050310313196600_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/mmy\/myw055","article-title":"CANDIPOP Project; GEIH-GEMICOMED (SEIMC) and REIPI. 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