{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:22:54Z","timestamp":1793305374354,"version":"4.5.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009002","name":"Ministry of Education and Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The World Health Organization (WHO) in 2022 developed a fungal priority pathogen list. Candida auris was ultimately ranked as a critical priority pathogen. PubMed and Web of Science were used to find studies published from 1 January 2011 to 18 February 2021, reporting on predefined criteria including: mortality, morbidity (i.e., hospitalization and disability), drug resistance, preventability, yearly incidence, and distribution\/emergence. Thirty-seven studies were included in the final analysis. The overall and 30-day mortality rates associated with C. auris candidaemia ranged from 29% to 62% and 23% to 67%, respectively. The median length of hospital stay was 46\u201368\u2009days, ranging up to 140\u2009days. Late-onset complications of C. auris candidaemia included metastatic septic complications. Resistance rates to fluconazole were as high as 87%\u2013100%. Susceptibility to isavuconazole, itraconazole, and posaconazole varied with MIC90 values of 0.06\u20131.0\u2009mg\/l. Resistance rates to voriconazole ranged widely from 28% to 98%. Resistance rates ranged between 8% and 35% for amphotericin B and 0%\u20138% for echinocandins. Over the last ten years, outbreaks due to C. auris have been reported in in all WHO regions. Given the outbreak potential of C. auris, the emergence and spread of MDR strains, and the challenges associated with its identification, and eradication of its environmental sources in healthcare settings, prevention and control measures based on the identified risk factors should be evaluated for their effectiveness and feasibility. Global surveillance studies could better inform the incidence rates and distribution patterns to evaluate the global burden of C. auris infections.<\/jats:p>","DOI":"10.1093\/mmy\/myae042","type":"journal-article","created":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T23:41:49Z","timestamp":1714347709000},"source":"Crossref","is-referenced-by-count":105,"title":["<i>Candida auris<\/i>\n                    \u2014a systematic review to inform the world health organization fungal priority pathogens list"],"prefix":"10.1093","volume":"62","author":[{"suffix":"PhD","given":"Hannah Yejin","family":"Kim","sequence":"first","affiliation":[{"name":"Sydney Infectious Disease Institute, The University of Sydney , Sydney, NSW , Australia"},{"name":"Faculty of Medicine and Health, School of Pharmacy, The University of Sydney , Sydney, New South Wales , Australia"},{"name":"Westmead Hospital, NSW Health , Westmead, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MSc","given":"Thi Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Pharmacy, The University of Sydney , Sydney, New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5957-4178","authenticated-orcid":false,"suffix":"PhD","given":"Sarah","family":"Kidd","sequence":"additional","affiliation":[{"name":"National Mycology Reference Centre, Microbiology and Infectious Diseases, SA Pathology , Adelaide, South Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MD","given":"Joshua","family":"Chambers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Pharmacy, The University of Sydney , Sydney, New South Wales , 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Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"suffix":"MD","given":"Arunoloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Director of the WHO CC for Mycology , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Beyer","sequence":"additional","affiliation":[{"name":"AMR Division, WHO , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"PhD","given":"Valeria","family":"Gigante","sequence":"additional","affiliation":[{"name":"AMR Division, WHO , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1978-1559","authenticated-orcid":false,"suffix":"PhD","given":"Justin","family":"Beardsley","sequence":"additional","affiliation":[{"name":"Sydney Infectious Disease Institute, The University of Sydney , Sydney, NSW , 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