{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:57:39Z","timestamp":1791813459751,"version":"4.3.4"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009002","name":"Ministry of Education and Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida albicans is a common fungal pathogen and amongst the leading causes of invasive candidiasis globally. This systematic review examines the characteristics and global impact of invasive infections caused by C. albicans. We searched on PubMed and Web of Science for studies reporting on criteria such as mortality, morbidity, drug resistance, preventability, yearly incidence, and distribution\/emergence during the period from 2016 to 2021. Our findings indicate that C. albicans is the most common Candida species causing invasive disease and that standard infection control measures are the primary means of prevention. However, we found high rates of mortality associated with infections caused by C. albicans. Furthermore, there is a lack of data on complications and sequelae. Resistance to commonly used antifungals remains rare. Although, whilst generally susceptible to azoles, we found some evidence of increasing resistance, particularly in middle-income settings\u2014notably, data from low-income settings were limited. Candida albicans remains susceptible to echinocandins, amphotericin B, and flucytosine. We observed evidence of a decreasing proportion of infections caused by C. albicans relative to other Candida species, although detailed epidemiological studies are needed to confirm this trend. More robust data on attributable mortality, complications, and sequelae are needed to understand the full extent of the impact of invasive C. albicans infections.<\/jats:p>","DOI":"10.1093\/mmy\/myae045","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T15:42:33Z","timestamp":1714232553000},"source":"Crossref","is-referenced-by-count":88,"title":["<i>Candida albicans<\/i>\n                    \u2014A systematic review to inform the World Health Organization Fungal Priority Pathogens List"],"prefix":"10.1093","volume":"62","author":[{"given":"Sarika","family":"Parambath","sequence":"first","affiliation":[{"name":"Sydney Infectious Diseases Institute, The University of Sydney , Sydney, NSW , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-2975","authenticated-orcid":false,"given":"Aiken","family":"Dao","sequence":"additional","affiliation":[{"name":"Sydney Infectious Diseases Institute, 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Witwatersrand , Johannesburg , South Africa"},{"name":"Institute of Infection and Immunity, St George's University of London , London , UK"},{"name":"MRC Centre for Medical Mycology, University of Exeter , Exeter , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-3345","authenticated-orcid":false,"given":"Rita","family":"Oladele","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Colombo","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-0960","authenticated-orcid":false,"given":"Tania","family":"Sorrell","sequence":"additional","affiliation":[{"name":"Sydney Infectious Diseases 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