{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:15:45Z","timestamp":1790468145524,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/003448"],"award-info":[{"award-number":["EMR\/2017\/003448"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["AMR\/160\/2018\/-ECD-II"],"award-info":[{"award-number":["AMR\/160\/2018\/-ECD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acrophialophora is implicated in superficial and invasive infections, especially in immunosuppressed individuals. The present study was undertaken to provide clinical, microbiological, phylogenetic, and antifungal susceptibility testing (AFST) profile of Acrophialophora isolated from India. All the isolates identified as Acrophialophora species at the National Culture Collection for Pathogenic Fungi, Chandigarh, India were revived. Phenotypic and molecular characterization was performed, followed by temperature studies, scanning electron microscopy (SEM), and AFST. We also performed systematic review of all the cases of Acrophialophora species reported till date. A total of nine isolates identified as Acrophialophora species were identified by molecular method as A. fusispora (n\u00a0=\u00a08) and A. levis (n\u00a0=\u00a01), from brain abscess (n\u00a0=\u00a04), respiratory tract (n\u00a0=\u00a03), and corneal scraping (n\u00a0=\u00a02). All patients but two had predisposing factors\/co-morbidities. Acrophialophora was identified as mere colonizer in one. Temperature studies and SEM divulged variation between both species. Sequencing of the internal transcribed spacer ribosomal DNA and beta-tubulin loci could distinguish species, while the LSU ribosomal DNA locus could not. AFST showed the lowest minimum inhibitory concentrations (MICs) for triazoles and the highest for echinocandins. Systematic literature review revealed 16 cases (11 studies), with ocular infections, pulmonary and central nervous system infections, and A. fusispora was common species. All the patients except three responded well. High MICs were noted for fluconazole, micafungin, and caspofungin. This is the first study delineating clinical, phenotypic, and genotypic characteristics of Acrophialophora species from India. The study highlights microscopic differences between both species and emphasizes the role of molecular methods in precise identification. Triazoles appear to be the most effective antifungals for managing patients.<\/jats:p>","DOI":"10.1093\/mmy\/myae061","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:38:41Z","timestamp":1718062721000},"source":"Crossref","is-referenced-by-count":5,"title":["Clinical spectrum, phenotypic and molecular characterization, and antifungal susceptibility of an emerging human pathogen, <i>Acrophialophora<\/i>, from India"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4871-8113","authenticated-orcid":false,"given":"Harsimran","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research , Chandigarh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parakriti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Government Medical College and Hospital , Chandigarh , 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