{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:35:22Z","timestamp":1790562922803,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Though echinocandins are the first line of therapy for C. auris candidemia, there is little clinical data to guide the choice of therapy within this class. This was the first study to compare the three echinocandins in terms of efficacy and outcomes for C. auris candidemia. This was a retrospective analysis of 82 episodes of candidemia caused by C. auris comparing outcomes across the three echinocandins. Majority patients in our study were treated with micafungin. Susceptibility rates were the lowest for caspofungin (35.36% resistance), with no resistance reported for the other two echinocandins. When a susceptible echinocandin was chosen, caspofungin resistance was not a factor significantly associated with mortality. Also, when a susceptible echinocandin was used for therapy, the choice within the class did not affect clinical cure, microbiological cure, or mortality (P\u00a0&amp;gt;\u00a00.05 for all). Failure to achieve microbiological cure (P\u00a0=\u00a00.018) and receipt of immune-modulatory therapy (P\u00a0=\u00a00.01) were significantly associated with increased mortality. Significant cost variation was noted among the echinocandins. Considering the significant cost variation, comparable efficacies can be reassuring for the prescribing physician.<\/jats:p>","DOI":"10.1093\/mmy\/myae065","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:52:13Z","timestamp":1719363133000},"source":"Crossref","is-referenced-by-count":14,"title":["Comparative efficacies of the three echinocandins for <i>Candida auris<\/i> candidemia: real world evidence from a tertiary centre in India"],"prefix":"10.1093","volume":"62","author":[{"given":"Parikshit S","family":"Prayag","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Deenanath Mangeshkar Hospital , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sampada A","family":"Patwardhan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Deenanath Mangeshkar Hospital , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasika S","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Deenanath Mangeshkar Hospital , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surabhi","family":"Dhupad","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Deenanath Mangeshkar Hospital , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejashree","family":"Rane","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Deenanath Mangeshkar Hospital , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2498-9576","authenticated-orcid":false,"given":"Amrita P","family":"Prayag","sequence":"additional","affiliation":[{"name":"Department of In house research, Deenanath Mangeshkar Hospital , Pune , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"issue":"7","key":"2024071614412669400_bib1","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3201\/eid2907.230540","article-title":"Candida auris\u2012associated hospitalizations, United States, 2017-2022","volume":"29","author":"Benedict","year":"2023","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"2024071614412669400_bib2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3947\/ic.2022.0008","article-title":"Candida auris: an overview of the emerging drug-resistant fungal infection","volume":"54","author":"Sanyaolu","year":"2022","journal-title":"Infect Chemother"},{"issue":"2","key":"2024071614412669400_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00134-014-3603-2","article-title":"Incidence, characteristics and outcome of ICU-acquired candidemia in 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