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The aim of this study was to determine plasma ITZ concentrations in cats with sporotrichosis treated with ITZ as monotherapy or in combination with potassium iodide (KI). Cats diagnosed with sporotrichosis received orally ITZ (100\u00a0mg\/cat\/day) or combination therapy with ITZ (100\u00a0mg\/cat\/day) and KI (2.5\u20135\u00a0mg\/kg\/day) in the case of worsening or stagnation of the clinical condition. At each monthly visit, blood samples were collected at an interval of 4\u00a0h for analysis of trough and peak plasma ITZ concentrations by HPLC. Clinical features and laboratory parameters were evaluated during follow-up. Sixteen cats were included in the study. The median plasma ITZ concentration of all cats was 0.75\u00a0\u00b5g\/mL. The median plasma ITZ concentration was 0.5\u00a0\u00b5g\/mL in cats that received ITZ monotherapy (n\u00a0=\u00a012) and 1.0\u00a0\u00b5g\/mL in those treated with ITZ\u00a0+\u00a0KI (n\u00a0=\u00a04). The clinical cure rate was 56.3% (n\u00a0=\u00a09) and the median treatment duration was 8 weeks. Nine cats (56.3%) developed adverse clinical reactions, and hyporexia was the most frequent (n\u00a0=\u00a08; 88.9%). Serum alanine aminotransferase was elevated in four cats (25%). The median plasma ITZ concentration detected in cats was considered to be therapeutic (&amp;gt;0.5\u00a0\u00b5g\/mL) and was reached after 4 weeks of treatment. Plasma ITZ concentrations were higher in cats that received ITZ\u00a0+\u00a0KI compared to those treated only with ITZ, suggesting pharmacokinetic synergism between these drugs.<\/jats:p>","DOI":"10.1093\/mmy\/myae076","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T05:17:27Z","timestamp":1721884647000},"source":"Crossref","is-referenced-by-count":3,"title":["Plasma itraconazole concentrations during treatment of feline sporotrichosis"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5022-9100","authenticated-orcid":false,"given":"Gabriela Reis","family":"Pereira-Oliveira","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Dib Ferreira","family":"Gremi\u00e3o","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lopes","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Caroline\u00a0dos\u00a0Santos\u00a0Honorato","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Gon\u00e7alves\u00a0Viana","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Barreto Fernandes","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-5631","authenticated-orcid":false,"given":"J\u00e9ssica Sep\u00falveda","family":"Boechat","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9rica","family":"Guerino\u00a0dos\u00a0Reis","sequence":"additional","affiliation":[{"name":"Biosafety Advisory, Quality Vice-Directory, The Institute of Technology on Immunobiologicals (Bio-Manguinhos), Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel de Vasconcelos Carvalhaes","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Epidemiology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Campos de Azevedo","family":"da\u00a0Silva","sequence":"additional","affiliation":[{"name":"Equivalence and Pharmacokinetics Service (Sefar), Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Santana","family":"Novotny","sequence":"additional","affiliation":[{"name":"Medicines Sector, National Institute for Quality Control in Health (INCQS), Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusiele","family":"Guaraldo","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory on Acute Febrile Illnesses, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro Antonio","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research on Dermatozoonoses in Domestic Animals, Oswaldo Cruz Foundation (Fiocruz) , Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"2024080716091911000_bib1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.diagmicrobio.2014.01.004","article-title":"Genotyping species of the Sporothrix schenckii complex by PCR-RFLP of 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