{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:08:57Z","timestamp":1753877337974,"version":"3.41.2"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["20220919Y035"],"award-info":[{"award-number":["20220919Y035"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Talaromycosis marneffei (T.M) is the primary opportunistic infection of AIDS patients, and its morbidity and mortality are extremely high. To further clarify the disease characteristics of patients and provide a solid basis for in-depth exploration of their pathogenic mechanisms, we retrospectively summarized and analyzed their clinical data. We included all T.M patients tested for direct antiglobulin test (DAT) in the study. Interestingly, we found that AIDS-T.M patients had an extremely high rate of DAT positivity (92\/127, 72.44%). In univariate analysis, a positive DAT was associated with blood culture of TM (P\u00a0=\u00a0.021), hypoproteinemia (P\u00a0=\u00a0.001), anemia (P\u00a0=\u00a0.001), thrombocytopenia (P\u00a0=\u00a0.003), sepsis (P\u00a0=\u00a0.007), and Sequential Organ Failure Assessment (SOFA) (P\u00a0=\u00a0.001). Hypoproteinemia, anemia, SOFA, APTT\u00a0&amp;gt;\u00a032.6 s, and AST &amp;gt; 40\u00a0U\/l were studied by logistic regression. Logistic regression revealed that SOFA (OR\u00a0=\u00a01.311, P\u00a0=\u00a0.043), hypoproteinemia (OR\u00a0=\u00a00.308, P\u00a0=\u00a0.021), and anemia (OR\u00a0=\u00a00.19, P\u00a0=\u00a0.044) were associated with positive DAT. Positive DAT was associated with severe disease manifestations such as sepsis, and the DAT test is crucial in patients with fungemia.<\/jats:p>","DOI":"10.1093\/mmy\/myae077","type":"journal-article","created":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T02:04:53Z","timestamp":1723341893000},"source":"Crossref","is-referenced-by-count":0,"title":["Direct antiglobulin (Coombs) test in HIV-positive <i>Talaromycosis marneffei<\/i> patients"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8813-2555","authenticated-orcid":false,"given":"Mengyan","family":"Wang","sequence":"first","affiliation":[{"name":"Xixi Hospital of Hangzhou , Hangzhou 310023 , China"},{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University , Zhejiang 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Xixi Hospital of Hangzhou , Hangzhou 310023 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University , Zhejiang 310003 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"issue":"1","key":"2024081309375874700_bib1","doi-asserted-by":"crossref","first-page":"e0005122","DOI":"10.1128\/cmr.00051-22","article-title":"An overlooked and underrated endemic mycosis-talaromycosis and the pathogenic fungus Talaromyces marneffei","volume":"36","author":"Wang","year":"2023","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"2024081309375874700_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1186\/s12879-020-05260-8","article-title":"Burden of Talaromyces marneffei infection in people living with HIV\/AIDS in Asia during ART era: a systematic review and meta-analysis","volume":"20","author":"Qin","year":"2020","journal-title":"BMC Infect Dis"},{"issue":"1","key":"2024081309375874700_bib3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.7589\/2017-02-037","article-title":"Isolation of Talaromyces 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