{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:27:05Z","timestamp":1787009225756,"version":"build-2736575974"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida auris is a pathogen of growing public health concern worldwide. However, risk factors contributing to C. auris infection in patients colonized with C. auris remain unclear. Understanding these risk factors is crucial to prevent colonization-to-infection transition and devise effective preventive strategies. This study aimed to investigate risk factors associated with C. auris infection compared to colonization. The study included 97 patients who acquired laboratory-confirmed C. auris in either matrix-assisted laser desorption\/ionization-time of flight (MALDI-TOF) mass spectrometry or VITEK 2 system from October 2019 to June 2023. Baseline demographics and known risk factors associated with C. auris infection were collected from electronic medical records. The infection group had C. auris from a sterile site or non-sterile site with evidence of infection. The colonization group was followed up for a median of 30 days for any signs of infection. Associations between relevant variables and C. auris infection were assessed using multivariable logistic regression. The infection group (n\u00a0=\u00a031) was more likely to be bedbound, with longer hospital stays and more arterial catheters. Chronic kidney disease (odds ratio [OR] 45.070), carriage of multidrug-resistant organisms (OR 64.612), and vasopressor use for &amp;gt; 20 days (OR 68.994) were associated with C. auris infection, after adjusting for sex, age, and prior colonization with C. auris. Chronic kidney disease, carriage of multidrug-resistant organisms, and prolonged vasopressor use emerged as significant risk factors for C. auris infection compared to colonization. They could be used to predict C. auris infection early in patients colonized with C. auris.<\/jats:p>","DOI":"10.1093\/mmy\/myae086","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T10:17:18Z","timestamp":1723717038000},"source":"Crossref","is-referenced-by-count":10,"title":["<i>Candida auris<\/i>\n                    : Understanding the dynamics of\n                    <i>C. auris<\/i>\n                    infection versus colonization"],"prefix":"10.1093","volume":"62","author":[{"given":"Sungsoo","family":"Park","sequence":"first","affiliation":[{"name":"Division of Medicine, Sheikh Khalifa Specialty Hospital , Ras Al Khaimah , UAE"},{"name":"Department of Pulmonology, Seoul National University Hospital , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heesuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Environmental Safety Healthcare Provider Team, Sheikh Khalifa Specialty Hospital , Ras Al Khaimah , UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duckjin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Sheikh Khalifa Specialty Hospital , Ras Al Khaimah , UAE"},{"name":"Department of Laboratory Medicine, Seoul National University Hospital , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-1905","authenticated-orcid":false,"given":"Hyeyoung","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Medicine, Sheikh Khalifa Specialty Hospital , Ras Al Khaimah , UAE"},{"name":"Environmental Safety Healthcare Provider Team, Sheikh Khalifa Specialty Hospital , Ras Al Khaimah , UAE"},{"name":"Department of Family Medicine, Seoul National University Hospital , Seoul , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"issue":"2","key":"2024090608310953900_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3390\/microorganisms8020181","article-title":"Candida auris, an agent of hospital-associated outbreaks: which challenging issues do we need to have in mind?","volume":"8","author":"Sabino","year":"2020","journal-title":"Microorganisms"},{"issue":"4","key":"2024090608310953900_bib2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.7326\/M22-3469","article-title":"Worsening spread of Candida auris in the United States, 2019 to 2021","volume":"176","author":"Lyman","year":"2023","journal-title":"Ann Intern Med"},{"issue":"4","key":"2024090608310953900_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jhin.2017.09.009","article-title":"Controlling a possible outbreak of Candida auris infection: lessons learnt from multiple interventions","volume":"97","author":"Biswal","year":"2017","journal-title":"J Hosp Infect"},{"key":"2024090608310953900_bib4","volume-title":"Candida auris","author":"Sikora","year":"2023"},{"key":"2024090608310953900_bib5","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3389\/fmicb.2019.02788","article-title":"Review on antifungal resistance mechanisms in the emerging pathogen Candida auris","volume":"10","author":"Chaabane","year":"2019","journal-title":"Front Microbiol"},{"key":"2024090608310953900_bib6","article-title":"Screening Recommendations for Healthcare Facilities","author":"Centers for Disease Control and Prevention","year":"2024"},{"issue":"4","key":"2024090608310953900_bib7","doi-asserted-by":"crossref","first-page":"e00578","DOI":"10.1002\/mbo3.578","article-title":"Candida auris: a systematic review and meta-analysis of current updates on an emerging multidrug-resistant pathogen","volume":"7","author":"Osei\u00a0Sekyere","year":"2018","journal-title":"Microbiol Open"},{"issue":"1","key":"2024090608310953900_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3201\/eid2301.161497","article-title":"Invasive infections with multidrug-resistant yeast Candida auris, Colombia","volume":"23","author":"Morales-L\u00f3pez","year":"2017","journal-title":"Emerg Infect. Dis"},{"key":"2024090608310953900_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/IDR.S116229","article-title":"Current perspective on emergence, diagnosis and drug resistance in Candida auris","volume":"10","author":"Sarma","year":"2017","journal-title":"Infect Drug Resist"},{"issue":"11","key":"2024090608310953900_bib10","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.3390\/jof8111126","article-title":"Candida auris: a mini review on epidemiology in healthcare facilities in Asia","volume":"8","author":"Thatchanamoorthy","year":"2022","journal-title":"J Fungi"},{"issue":"3","key":"2024090608310953900_bib11","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40121-022-00625-9","article-title":"Candida auris candidemia in critically ill, colonized patients: cumulative incidence and risk factors","volume":"11","author":"Briano","year":"2022","journal-title":"Infect Dis Ther"},{"issue":"11","key":"2024090608310953900_bib12","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.cmi.2020.02.001","article-title":"A clinical predictive model of candidaemia by Candida auris in previously colonized critically ill patients","volume":"26","author":"Garcia-Bustos","year":"2020","journal-title":"Clin Microbiol Infect"},{"issue":"10","key":"2024090608310953900_bib13","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/myc.13626","article-title":"Candida auris from colonisation to candidemia: a four-year study","volume":"66","author":"Mulet\u00a0Bayona","year":"2023","journal-title":"Mycoses"},{"issue":"11","key":"2024090608310953900_bib14","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/biology10111144","article-title":"Emerging status of multidrug-resistant bacteria and fungi in the Arabian Peninsula","volume":"10","author":"Borgio","year":"2021","journal-title":"Biology"},{"key":"2024090608310953900_bib15","author":"United Arab Emirates Ministry of Health & Prevention","year":"2022"},{"issue":"5","key":"2024090608310953900_bib16","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/cid\/ciad752","article-title":"Rapid environmental contamination with Candida auris and multidrug-resistant bacterial pathogens near colonized patients","volume":"78","author":"Sansom","year":"2024","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2024090608310953900_bib17","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/CCM.0b013e31819daa14","article-title":"Usefulness of the \u201cCandida score\u201d for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study","volume":"37","author":"Le\u00f3n","year":"2009","journal-title":"Crit Care Med"},{"issue":"1","key":"2024090608310953900_bib18","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13756-023-01285-1","article-title":"Comparison of microbial colonization rates between central venous catheters and peripherally inserted central catheters","volume":"12","author":"Pitiriga","year":"2023","journal-title":"Antimicrob Resist Infect Control"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myae086\/58839423\/myae086.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/62\/9\/myae086\/59030499\/myae086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/62\/9\/myae086\/59030499\/myae086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T04:31:25Z","timestamp":1725597085000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myae086\/7734769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9,6]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myae086","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,8,16]]},"article-number":"myae086"}}