{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:50:12Z","timestamp":1785163812951,"version":"3.55.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["405312\/2021-0"],"award-info":[{"award-number":["405312\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["305924\/2021-4"],"award-info":[{"award-number":["305924\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Candida parapsilosis species complex poses a recognized threat to the nosocomial environment. In the scenario of the global rise of resistant strains to antifungals, geraniol, a terpene isolated from different essential oils, has shown promising antimicrobial activity. We evaluated: (1) the effects of geraniol against the C. parapsilosis species complex, in planktonic and biofilm forms; (2) the strains\u2019 susceptibility to clinical antifungals and (3) the geraniol interaction with antifungals. Eighteen isolates were subjected to in vitro susceptibility testing by the broth microdilution protocol, using geraniol, amphotericin B, caspofungin, itraconazole and fluconazole to determine the minimum inhibitory concentration (MIC) and subsequently, we measured the fungicidal activity. Geraniol was tested against biofilms by the measurement of the metabolic activity and biomass. Pharmacological interactions were performed by the checkerboard method. Geraniol's MIC range was between 256 and 512\u00a0\u00b5g\/ml. MIC range for clinical antifungals was\u00a0\u2264\u00a00.031\u20134\u00a0\u00b5g\/ml. Geraniol also showed antibiofilm activity with average reductions of metabolic activity (38.33%) and biomass (30.69%), at MIC concentration. Furthermore, geraniol showed synergistic\/additive effects with antifungals. Briefly, geraniol inhibits both planktonic cells and biofilms of the C. parapsilosis species complex and besides it improves the efficacy of amphotericin B, caspofungin and fluconazole.<\/jats:p>","DOI":"10.1093\/mmy\/myae105","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T15:05:17Z","timestamp":1730300717000},"source":"Crossref","is-referenced-by-count":3,"title":["Geraniol inhibits both planktonic cells and biofilms of the <i>Candida parapsilosis<\/i> species complex: Highlight for the improved efficacy of amphotericin B, caspofungin and fluconazole plus Geraniol"],"prefix":"10.1093","volume":"62","author":[{"given":"Jos\u00e9 J\u00falio Costa","family":"Sidrim","sequence":"first","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Vieira","family":"Martins","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gleiciane","family":"da\u00a0Rocha","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9ssica dos Santos","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Veterinary Sciences, College of Veterinary, State University of Cear\u00e1, Fortaleza , Cear\u00e1 60714-903 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8386-2180","authenticated-orcid":false,"given":"Rossana de Aguiar","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia Morgana de Melo","family":"Guedes","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemiro de Aquino","family":"Pereira-Neto","sequence":"additional","affiliation":[{"name":"Department of Transport Engineering, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60455-760 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora de Souza Collares Maia","family":"Castelo-Branco","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-1734","authenticated-orcid":false,"given":"Marcos F\u00e1bio Gadelha","family":"Rocha","sequence":"additional","affiliation":[{"name":"Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Cear\u00e1, Fortaleza , Cear\u00e1 60430-160 ,","place":["Brazil"]},{"name":"Postgraduate Program in Veterinary Sciences, College of Veterinary, State University of Cear\u00e1, Fortaleza , Cear\u00e1 60714-903 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